AI Article Synopsis

  • - BioID is a technique used for identifying proteins that are in close proximity to a given protein in order to study their interactions and functions.
  • - GO refers to gene ontology, a framework for categorizing genes and their products based on their functions and biological processes.
  • - OSBPL, VAPA, and VAPB are types of proteins involved in cellular processes, with OSBPL relating to lipid binding and VAPA/B associated with vesicle transport in cells.

Article Abstract

BioID: proximity-dependent biotin identification; GO: gene ontology; OSBPL: oxysterol binding protein like; VAPA: VAMP associated protein A; VAPB: VAMP associated protein B and C.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196747PMC
http://dx.doi.org/10.1080/15548627.2021.1965711DOI Listing

Publication Analysis

Top Keywords

vamp associated
8
associated protein
8
global proximity
4
proximity interactome
4
interactome human
4
human macroautophagy
4
macroautophagy pathway
4
pathway bioid
4
bioid proximity-dependent
4
proximity-dependent biotin
4

Similar Publications

SiO/Si interferometers designed for on-site botulinum neurotoxin serotypes B and C quantification and biological activity assessment.

Biosens Bioelectron

December 2024

Institute of Agricultural Engineering, ARO, Volcani Institute, Rishon LeZion, 7505101, Israel. Electronic address:

Botulinum neurotoxins (BoNT), the agent causing botulism, exhibit the highest potency among bacterial toxins and pose a significant threat to both humans and animals. The current in vivo method (mouse lethality assay, MLA) is inappropriate for real-time and pen-side assessment of the occurring outbreak or case. Herein, we describe a reflective-based biosensor capable of detecting the toxin's type and activity state by competitive immunoassay and endopeptidase activity, respectively.

View Article and Find Full Text PDF

Many gram-negative pathogenic bacteria use type III effector proteins (T3Es) as essential virulence factors to suppress host immunity and to cause disease. However, in many cases the molecular function of T3Es remains unknown. The plant pathogen Xanthomonas campestris pv.

View Article and Find Full Text PDF

In-human clinical experience with direct stick embolization of low-flow vascular malformations using a mammalian target of rapamycin inhibitor.

J Vasc Surg Venous Lymphat Disord

November 2024

The Vascular Care Group (TVCG), Darien, CT; Vascular Anomalies and Malformations Program (VAMP), Yale School of Medicine, New Haven, CT; Division of Vascular Surgery, Department of Surgery, Yale New Haven Health, New Haven, CT. Electronic address:

Background: Although direct stick embolization (DSE) of low-flow vascular malformations (LFVMs) with off-label embolotherapeutic compounds is the current mainstay of therapy, systemic oral mammalian target of rapamycin (mTOR) inhibition has evolved into an important adjunctive therapy that is associated with frequent blood draws, systemic toxicity, and rebound signs and symptoms upon cessation. We herein report our experience with in-human DSE of LFVMs with an mTOR inhibitor for direct, intralesional targeting of the culprit mutated pathway without repeated systemic exposure.

Methods: Since 2020, 33 procedures involving DSE were performed in 25 patients with LFVMs using a patented formulation and technique involving the intravenously compatible mTOR inhibitor Yale-OCR7737, used as a liquid compound in a collagen matrix emulsion for added viscosity and intralesional residence.

View Article and Find Full Text PDF

Secretion of endoplasmic reticulum protein VAPB/ALS8 requires topological inversion.

Nat Commun

October 2024

Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.

VAMP-associated protein (VAP) is a type IV integral transmembrane protein at the endoplasmic reticulum (ER). Mutations in human VAPB/ALS8 are associated with amyotrophic lateral sclerosis (ALS). The N-terminal major sperm protein (MSP) domain of VAPB (Drosophila Vap33) is cleaved, secreted, and acts as a signaling ligand for several cell-surface receptors.

View Article and Find Full Text PDF

Circular RNAs (circRNA) have a vital role in the progression of cancers. For instance, circTP63 is upregulated in prostate cancer (PCa) tissues compared with adjacent normal tissues. However, the role of circTP63 in prostate cancer is still unclear.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: