AI Article Synopsis
- iNKT cells are a type of innate lymphocyte with invariant TCRs, considered promising for "off-the-shelf" treatments for various diseases.
- Their scarcity in human blood restricts their use in immunotherapy.
- A new 21-day method has been developed to significantly expand the number of iNKT cells ex vivo, enhancing their potential for therapeutic applications.
Article Abstract
iNKT cells, classified as innate lymphocytes with invariant TCRs, have been highlighted as a putative, "off-the-shelf" cellular immunotherapeutic strategy for the treatment of malignant and nonmalignant diseases. However, their paucity in human blood limits their immunotherapeutic applications. Herein we describe a rigorously optimized 21-day ex vivo expansion method to achieve log-fold increases in immunotherapeutic human iNKT cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733937 | PMC |
| http://dx.doi.org/10.1007/978-1-0716-1775-5_13 | DOI Listing |
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