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The Role of the Chronotype in Developing an Excessive Body Weight and Its Complications-A Narrative Review.
Nutrients
December 2024
Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznań University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland.
The chronotype, the personal predisposition towards morning or evening activities, significantly influences health conditions, sleep, and eating regulations. Individuals with evening chronotypes are often at a higher risk for weight gain due to misalignment between their natural tendencies of functioning and social schedules, resulting in insufficient sleep, disruptions in eating habits, and decreased physical activity levels. Often, impaired glucose tolerance and changes in melatonin, adiponectin, and leptin secretion, along with alterations in the clock gene functions in subjects with evening preferences, may be predisposed to obesity.
View Article and Find Full Text PDFData Mining Approach to Melatonin Treatment in Alzheimer's Disease: New Gene Targets and .
Int J Mol Sci
January 2025
Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
Melatonin is a hormone released by the pineal gland that regulates the sleep-wake cycle. It has been widely studied for its therapeutic effects on Alzheimer's disease (AD), particularly through the amyloidosis, oxidative stress, and neuroinflammation pathways. Nevertheless, the mechanisms through which it exerts its neuroprotective effects in AD are still largely unknown.
View Article and Find Full Text PDFChronic Dexamethasone Disturbs the Circadian Rhythm of Melatonin and Clock Genes in Goats.
Animals (Basel)
January 2025
Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Article Synopsis
- Dex, a drug used for its immunosuppressive and anti-inflammatory effects, disrupts melatonin secretion and biological clock gene expression in goats.
- After 21 days of Dex treatment, goats showed significantly lower melatonin levels in both plasma and colon, as well as decreased expression of AANAT, a key enzyme for melatonin synthesis.
- The circadian rhythms of several clock genes were disrupted in the Dex group, along with notable changes in CLOCK and BMAL1 protein levels, indicating that chronic Dex exposure affects biological rhythm regulation.
Applying Natural Language Processing Techniques to Map Trends in Insomnia Treatment Terms on the r/Insomnia Subreddit: Infodemiology Study.
J Med Internet Res
January 2025
Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States.
Background: People share health-related experiences and treatments, such as for insomnia, in digital communities. Natural language processing tools can be leveraged to understand the terms used in digital spaces to discuss insomnia and insomnia treatments.
Objective: The aim of this study is to summarize and chart trends of insomnia treatment terms on a digital insomnia message board.
Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponsored protocol.
PLoS One
January 2025
VA Portland Health Care System, Portland, Oregon, United States of America.
Sleep-wake disturbances frequently present in Veterans with mild traumatic brain injury (mTBI). These TBI-related sleep impairments confer significant burden and commonly exacerbate other functional impairments. Therapies to improve sleep following mTBI are limited and studies in Veterans are even more scarce.
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