Background And Aim: activity evaluation of Egyptian leaves extracts, and healing activity assessment of the newly prepared ointment of leaves extracts mingled with Shea butter.
Experimental Procedure: Different extraction methods and solvents were used to extract Egyptian bioactive agent(s). Antibacterial, scavenging activity and evaluation of wound repair potentiality of extract were examined in normal and diabetic experimental rat models with induced circular excisions.
Results And Conclusion: Olive leaves extract of Tanta was selected as the most active agent against Methicillin-resistant (MRSA), with MIC value 15.6 μg/ml. Moreover, checkerboard dilution technique approved that the interaction between Tanta LEM crude extract and Ciprofloxacin was synergistic. Scavenging activity of the extract against DPPH free radicals was 87.55% at concentration of 50 μg/ml. normal and diabetic experimental rats treated with Shea butter: Tanta LEM extract (1:3 w/v) showed the maximum wound contraction and healing activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427474 | PMC |
| http://dx.doi.org/10.1016/j.jtcme.2021.02.008 | DOI Listing |
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