Fibroblasts are a major non-neoplastic component of solid tumors, yet it is unclear whether they promote or oppose cancer. In this issue of Cancer Cell, Hutton et al. report two distinct fibroblast subpopulations that are defined by a single marker, one subpopulation that is tumor permissive and the other that is tumor suppressive and supports anti-tumor immunity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ccell.2021.07.022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Making sense of drug use and dependence-A scoping review of mass media interventions intended to reduce stigma towards people who use drugs.
Int J Drug Policy
October 2024
School of Psychological Science, University of Bristol, 12a Priory Road, Clifton, Bristol, UK.
Background: People who use drugs face entrenched stigma, which fosters shame, restricts service access, and exacerbates inequalities. The use of mass media in anti-stigma interventions offers an opportunity to challenge stigmatising attitudes at scale. There are, however, inconsistencies in messaging approaches used in mass media anti-stigma interventions, and how authors conceptualise and measure 'stigma'.
View Article and Find Full Text PDFThe challenge of downstream processing of spray dried amorphous solid dispersions into minitablets designed for the paediatric population - A sustainable product development approach.
Eur J Pharm Sci
May 2024
Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland; Helsinki Institute of Sustainability Science, HELSUS, Finland.
Poorly water-soluble drugs present a significant challenge in the development of oral solid dosage forms (OSDs). In formulation development the appropriate use of excipients to adjust solubility, and the choice of manufacturing method and pharmaceutical processes to obtain a dosage form to meet the needs of the patient group, is crucial. Preparing an amorphous solid dispersion (ASD) is a well-established method for solubility enhancement, and spray drying (SD) a common manufacturing method.
View Article and Find Full Text PDFClustering energy support beliefs to reveal unique sub-populations using self-organizing maps.
Heliyon
July 2023
School of Geosciences, University of Oklahoma, USA.
Americans' support for energy sources is quite complex and dependent on a range of socio-demographic characteristics. In a novel approach to investigate energy opinions on renewables and fossil fuels, self-organizing maps are employed to cluster individuals solely on their energy beliefs using social survey data collected from Pew Research in the Spring of 2021. These energy preference clusters are then used in regression models to examine attitudes regarding energy policy in the United States.
View Article and Find Full Text PDFPatterns of health lifestyle behaviours: findings from a representative sample of Israel.
BMC Public Health
November 2022
School of Behavioural Sciences, The Academic College of Tel Aviv-Yaffo, 6818211, Tel Aviv-Yaffo, Israel.
Background: Researchers are increasingly acknowledging the importance of understanding patterns of engagement in multiple, as opposed to isolated, health behaviours. Accordingly, several studies, targeting various geographical regions, have begun to identify and characterize unique classes of individuals in terms of their engagement in health behaviours, towards gaining insights that might guide tailored health interventions. Our study extends this stream of research to the Israeli context, as well as examines whether certain sociodemographic characteristics tend to be associated with affiliation to a specific group of individuals, i.
View Article and Find Full Text PDFApplication of archaeological concepts to the interpretation of RNA virus quasi species evolution.
Theor Biol Forum
January 2022
Laboratory of RNA Archaeology, Instituto de Parasitología y Biomedicina "López-Neyra" (CSIC), Granada, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain, Corresponding Author.
An enduring problem concerning the evolution of RNA viruses stems from the fact that their long-term rates of evolution (substitutions/ site/year) are lower than those calculated by comparing sequences of isolates collected over short time periods or within a single host (shortterm or intra-host evolution). This inconsistency has been attributed to several reasons, including deviations from the assumption of a molecularclock (constancy of mutational inputs as a function of time) and variations in viral multiplication rates, among others. We previously proposed a non-phylogenetic method for extracting information contained in mRNAs, that cannot be identified from examination of primary sequences alone, and that we called «archaeological» information.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!