N-heterocyclic carbene (NHC) metal complexes have gained an incredible amount of attention in the course of the last two decades and have become indispensable as an intricate part of a plethora of applications. The areas of their synthesis and derivatization are constantly evolving and bring new, more sustainable, cost-effective and simpler approaches to the design of existing and next generation catalysts and materials. This article provides an overview of the latest developments, focusing on those which have appeared during the last two years.
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http://dx.doi.org/10.1039/d1dt01847g | DOI Listing |
Angew Chem Int Ed Engl
January 2025
Sichuan University, State Key Laboratory of Biotherapy, CHINA.
Herein we report a cobalt-catalyzed hydroglycosylation of terminal alkynes, employing bench-stable ortho-iodobiphenyl (oIB) substituted sulfides as glycosyl donors. This reaction occurs with high stereo- and regioselectivity to afford E-configured vinyl α-C-glycosides, a class of compounds nontrivial to access by previous methods. The use of a bis(oxazoline) ligand with bulky side chains is critical for the high selectivities observed.
View Article and Find Full Text PDFOrg Lett
January 2025
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, China.
Genome mining of NBU2194 resulted in the identification of a family of 17-membered macrolides, neptunizhulides A-F. Their structures were elucidated by comprehensive spectroscopic data analysis. Stereochemical assignments of the neptunizhulides were determined by -based configuration analysis, ROESY NMR, Mosher's ester derivatization, and bioinformatic predictions.
View Article and Find Full Text PDFJ Org Chem
January 2025
College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou 311121, China.
In the vanguard of sustainable chemistry, the pursuit of efficient pathways for the synthesis of alkyl bicyclo[1.1.1]pentane-heteroaryls has captured the attention of the scientific vanguard.
View Article and Find Full Text PDFAnal Chem
January 2025
Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina 28081, United States.
Double bond (C═C) position isomerism in unsaturated lipids can indicate abnormal lipid metabolism and pathological conditions. Novel chemical derivatization and mass spectrometry-based techniques are under continuing development to provide more accurate elucidation of lipid structure in finer structural detail. Here, we introduce a new ion chemistry for annotating lipid C═C positions, which is highly efficient for liquid chromatography-mass spectrometry-based lipidomics.
View Article and Find Full Text PDFMethods Mol Biol
January 2025
Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Functionally derivatized analogs of prenyl lipids are valuable tools for the detection and analysis of prenylated proteins. Using a biotinylated analog of geranylgeranyl, we previously identified Ykt6 as a substrate for a novel protein prenyltransferase, termed geranylgeranyltransferase type III (GGTase-III). Ykt6 is an evolutionarily highly conserved SNARE protein that regulates multiple intracellular trafficking pathways, including intra-Golgi trafficking and autophagosome-lysosome fusion.
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