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Neighborhood-level measures of socioeconomic status impact healthcare utilization and surgical outcomes in cervical spondylotic myelopathy patients in the Deep South.
J Neurosurg Spine
January 2025
2Department of Neurosurgery, University of Alabama at Birmingham, Alabama.
Objective: The aim of this study was to evaluate the association of neighborhood-level and individual-level measures of socioeconomic status with readmission, complication rates, and postoperative length of stay of patients with cervical spondylotic myelopathy (CSM) in the Deep South.
Methods: The authors identified all patients undergoing surgical intervention for the treatment of CSM from November 2010 to February 2022 using Current Procedural Terminology and ICD-9/ICD-10 codes. Patient demographic, socioeconomic, perioperative, and postoperative data for each patient were collected via review of the electronic medical record.
Integrating Pharmacogenomics into the Broader Construct of Genomic Medicine: Efforts by the ClinGen Pharmacogenomics Working Group (PGxWG).
Clin Chem
January 2025
Departments of Biomedical Data Science, Medicine (BMIR) & Genetics, Stanford University, Stanford, CA, United States.
Pharmacogenomics (PGx) is focused on the relationship between an individual's genetic makeup and their response to medications, with the overarching aim of guiding prescribing decisions to improve drug efficacy and reduce adverse events. The PGx and genomic medicine communities have worked independently for over 2 decades, developing separate standards and terminology, making implementation of PGx across all areas of genomic medicine difficult. To address this issue, the Clinical Genome Resource (ClinGen) Pharmacogenomics Working Group (PGxWG) was established by the National Institutes of Health (NIH)-funded ClinGen to initially create frameworks for evaluating gene-drug response clinical validity and actionability aligned with the ClinGen frameworks for evaluating monogenic gene-disease relationships, and a framework for classifying germline PGx variants similar to the American College of Medical Genetics (ACMG) and Association of Molecular Pathology (AMP) system for interpretation of disease-causing variants.
View Article and Find Full Text PDFCardiac events and dynamic echocardiographic and electrocardiogram changes following osimertinib treatment in lung cancer.
Front Cardiovasc Med
December 2024
Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Osimertinib is first-line treatment for epidermal growth factor (EGFR)-mutated non-small cell lung cancer (NSCLC) and has been associated with cardiotoxicity. However, the nature of cardiac remodeling and associated risk factors remains incompletely understood. Retrospective analysis of NSCLC patients with ≥1 echocardiogram post-osimertinib between 2007 and 2022 was performed.
View Article and Find Full Text PDFBibliometric Analysis of Peer-Reviewed Literature on Erosive Tooth Wear From 1945 to 2023.
Cureus
November 2024
College of Dentistry, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Erosive tooth wear (ETW) is a prevalent oral condition with varying etiology, including erosion, abrasion, abfraction, and attrition. It is reported in the literature in different nomenclatures, hindering the ability to identify the emerging trends and influential scholarly works and bodies within this field. Using a bibliometric analysis approach, this study aims to evaluate the trends, themes, and productivity of the research on ETW condition while respecting its different terminologies.
View Article and Find Full Text PDFDefinitions, epidemiology, and outcomes of persistent/chronic critical illness: a scoping review for translation to clinical practice.
Crit Care
December 2024
Department of Critical Care Medicine, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Background: Medical advances in intensive care units (ICUs) have resulted in the emergence of a new patient population-those who survive the initial acute phase of critical illness, but require prolonged ICU stays and develop chronic critical symptoms. This condition, often termed Persistent Critical Illness (PerCI) or Chronic Critical Illness (CCI), remains poorly understood and inconsistently reported across studies, resulting in a lack of clinical practice use. This scoping review aims to systematically review and synthesize the existing literature on PerCI/CCI, with a focus on definitions, epidemiology, and outcomes for its translation to clinical practice.
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