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| http://dx.doi.org/10.1111/cup.14133 | DOI Listing |
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MRPL24 drives breast cancer metastasis and stemness by targeting c-MYC, BRD4, and STAT3.
3 Biotech
February 2025
Key Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, University of Shanghai for Science and Technology, Shanghai, 200093 China.
Unlabelled: The study aims to investigate the clinicopathological significance of MRPL24 in human cancers, with a particular focus on breast cancer (BC). Comprehensive bioinformatics analyses were conducted using data from The Cancer Genome Atlas (TCGA) and various advanced database, including cBioPortal, UALCAN, TIMER, Prognoscan, TISIDB, KM Plotter, and The Human Protein Atlas, to provide a detailed evaluation of MRPL55's role in cancer. The findings were further validated through experimental studies.
View Article and Find Full Text PDFDiagnostic Imaging Performance of Dual-Energy Computed Tomography Compared with Conventional Computed Tomography and Magnetic Resonance Imaging for Uterine Cervical Cancer.
Indian J Radiol Imaging
October 2024
Department of Radiology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
This article evaluates the ability of low-energy (40 keV) virtual monoenergetic images (VMIs) in the local diagnosis of cervical cancer compared with that of conventional computed tomography (C-CT) and magnetic resonance imaging (MRI), using clinicopathologic staging as a reference. This prospective study included 33 patients with pathologically confirmed cervical cancer who underwent dual-energy CT and MRI between 2021 and 2022. The contrast-to-noise ratio (CNR) of the tumor-to-myometrium was compared between C-CT and VMI.
View Article and Find Full Text PDFPD-L1 expression in non-small cell lung carcinoma in Latin America: a systematic review and meta-analysis.
Transl Lung Cancer Res
July 2024
Department of Epidemiology, Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, Colombia.
Background: Programmed cell death ligand 1 (PD-L1) expression in non-small cell lung carcinoma (NSCLC) is a crucial factor in predicting responses to immunotherapy. This systematic review and meta-analysis focuses on the prevalence of PD-L1 expression and clinicopathological features among Hispanic/Latino (H/L) populations.
Methods: Embase, LILACS, Medline, and Virtual Health Library were searched for studies that evaluated the prevalence of PD-L1 in H/L patients.
[Preoperative prediction of HER-2 expression status in breast cancer based on MRI radiomics model].
Zhonghua Zhong Liu Za Zhi
May 2024
Department of Medical Imaging, the Affiliated People's Hospital of Jiangsu University, Zhenjiang 212002, China.
Article Synopsis
- The study investigates the effectiveness of T2-weighted imaging, apparent diffusion coefficient, and enhanced MRI techniques in predicting HER-2 status in breast cancer patients.
- A sample of 187 patients from Zhenjiang First People's Hospital was analyzed, with 48 being HER-2 positive and 139 HER-2 negative, using various imaging modalities and statistical methods to develop predictive models.
- The research employed logistic regression and nomograms, evaluating model performance through ROC curves and decision curve analysis to assess clinical utility.
Added value of 40 keV virtual monoenergetic images for diagnosing malignant pleural effusion on chest CT.
Jpn J Radiol
August 2024
Department of Radiology, Gyeongsang National University Changwon Hospital, 555 Samjeongja-dong, Seongsan-gu, Changwon, Republic of Korea.
Objective: This study aimed to evaluate the added value of 40 keV virtual mono-energetic images (VMIs) obtained from dual-layer detector CT (DLCT) for diagnosing malignant pleural effusion (MPE) in patients presenting with unilateral pleural effusion on chest CT.
Materials And Methods: This retrospective study included 75 patients with unilateral pleural effusion who underwent contrast-enhanced chest CT scans using DLCT. Quantitative and qualitative assessments of the visibility of pleural thickening were conducted on both conventional 120 kVp images and 40 keV VMIs.
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