The enantioselective copper-catalyzed oxidative coupling of alkenols with styrenes for the construction of dihydropyrans, isochromans, pyrans and morpholines is reported. A concise formal synthesis of a σ receptor ligand using this alkene carboetherification methodology was demonstrated. Ligand, solvent and base all impact reaction efficiency. DFT transition state calculations are presented.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590114 | PMC |
| http://dx.doi.org/10.1039/d1cc03515k | DOI Listing |
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