Objective: To determine whether the bihormonal bionic pancreas (BHBP) improves glycemic control and reduces hypoglycemia in individuals with congenital hyperinsulinism (HI) and postpancreatectomy diabetes (PPD) compared with usual care (UC).
Research Design And Methods: Ten subjects with HI and PPD completed this open-label, crossover pilot study. Coprimary outcomes were mean glucose concentration and time with continuous glucose monitoring (CGM) glucose concentration <3.3 mmol/L.
Results: Mean (SD) CGM glucose concentration was 8.3 (0.7) mmol/L in the BHBP period versus 9 (1.8) mmol/L in the UC period ( = 0.13). Mean (SD) time with CGM glucose concentration <3.3 mmol/L was 0% (0.002) in the BHBP period vs. 1.3% (0.018) in the UC period ( = 0.11).
Conclusions: Relative to UC, the BHBP resulted in comparable glycemic control in our population.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546273 | PMC |
| http://dx.doi.org/10.2337/dc21-0416 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Bihormonal Bionic Pancreas Improves Glycemic Control in Individuals With Hyperinsulinism and Postpancreatectomy Diabetes: A Pilot Study.
Diabetes Care
November 2021
Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA
Objective: To determine whether the bihormonal bionic pancreas (BHBP) improves glycemic control and reduces hypoglycemia in individuals with congenital hyperinsulinism (HI) and postpancreatectomy diabetes (PPD) compared with usual care (UC).
Research Design And Methods: Ten subjects with HI and PPD completed this open-label, crossover pilot study. Coprimary outcomes were mean glucose concentration and time with continuous glucose monitoring (CGM) glucose concentration <3.
Automated glycemic control with the bionic pancreas in cystic fibrosis-related diabetes: A pilot study.
J Cyst Fibros
January 2020
Diabetes Research Unit, Massachusetts General Hospital, Boston, MA, United States of America; Department of Endocrinology, Boston Children's Hospital, Boston, MA, United States of America. Electronic address:
Cystic fibrosis-related diabetes (CFRD) is the most common extrapulmonary manifestation of cystic fibrosis. The current standard of care for CFRD involves treatment with insulin, typically via multiple daily injections. We conducted a small pilot study comparing usual care with automated glycemic control using the bihormonal (insulin and glucagon) and insulin-only configurations of the bionic pancreas.
View Article and Find Full Text PDFImpact of an Automated Bihormonal Delivery System on Psychosocial Outcomes in Adults with Type 1 Diabetes.
Diabetes Technol Ther
December 2017
2 University of California, Department of Family and Community Medicine, San Francisco, San Francisco, California.
Objectives: The study assessed the psychosocial impact of the bihormonal bionic pancreas (BP) on adults in a real-world outpatient setting.
Research Design And Methods: Thirty-nine adults with type 1 diabetes at four study centers across the U.S.
Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover trial.
Lancet
January 2017
Diabetes Unit and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address:
Background: The safety and effectiveness of a continuous, day-and-night automated glycaemic control system using insulin and glucagon has not been shown in a free-living, home-use setting. We aimed to assess whether bihormonal bionic pancreas initialised only with body mass can safely reduce mean glycaemia and hypoglycaemia in adults with type 1 diabetes who were living at home and participating in their normal daily routines without restrictions on diet or physical activity.
Methods: We did a random-order crossover study in volunteers at least 18 years old who had type 1 diabetes and lived within a 30 min drive of four sites in the USA.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!