Production of acceptable quality ejaculates in boars is dependent upon the Sertoli cell population established before puberty and how effectively these cells function after sexual maturity. In general, factors affecting Sertoli cell mitosis tend to have a two-fold greater effect on sperm production compared with those affecting spermatogenesis. Birthweight is a reliable indicator of in utero testicular development and prepubertal growth rates are positively correlated with testis size and sperm production after sexual maturity. Colostrum intake and pre-weaning nutrition account for much of the variation associated with quality and quantity of ejaculates and represent opportunities to further enhance lifetime sperm production. Interactions between young boars and humans, shortly after weaning, have important effects on spermatogenesis after sexual maturity and need to be studied further. The seasonal effect on depression in semen quality is the most significant factor affecting production of acceptable quality ejaculates after puberty. Ambient temperatures, greater than those of the thermoneutral zone, have both acute and chronic effects that compromise all aspects of the male reproductive axis. Identification of genes associated with heat-tolerant phenotypes holds promise for addressing this challenge, especially in light of the current trend in global warming. Supplementation of vitamins, minerals and other compounds have positive effects on sperm production during periods in which other stressors, especially heat stress, are present and is an important mitigation strategy. Recent information on housing conditions and boar usage patterns indicate these cause relatively minor changes in sperm production, overall, but for some males can have significant, long-term effects.
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http://dx.doi.org/10.1016/j.anireprosci.2021.106840 | DOI Listing |
Sci Rep
January 2025
Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Spermatogenesis is one of the most complex processes of cell differentiation and its failure is a major cause of male infertility. Therefore, a proper model that recapitulates spermatogenesis in vitro has been long sought out for basic and clinical research. Testis organ culture using the gas-liquid interphase method has been shown to support spermatogenesis in mice and rats.
View Article and Find Full Text PDFJ Endocr Soc
November 2024
Division of Endocrinology, Metabolism and Diabetes, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
"Pseudo-endocrine disorders" refer to proposed conditions that have never been scientifically proven to exist but, due to widespread misinformation available on the internet and other media, are relatively commonly diagnosed and treated with equally unproven and sometimes dangerous treatments. Adrenal fatigue is a nonexistent condition that supposedly results from adrenal exhaustion and atrophy due to chronic stress and has been promoted as a potential explanation for a variety of symptoms. Testing consists of nonvalidated online surveys and salivary cortisol profiles while treatment is not evidence-based at best and can be dangerous.
View Article and Find Full Text PDFFree Radic Biol Med
December 2024
Laboratory of Reproductive Endocrinology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-4-4, Kagamiyama, Higashihiroshima, Hiroshima, 7398528, Japan. Electronic address:
Sperm cells are highly susceptible to oxidative stress, which decreases their motility and fertility. However, glutathione (GSH) plays a critical role in protecting sperm cells from oxidative damage, a common byproduct of mitochondrial oxidative phosphorylation. On the other hand, GSH biosynthesis in sperm is limited by the availability of cysteine (Cys), which is inherently unstable and found at low concentrations in boar seminal plasma.
View Article and Find Full Text PDFMol Biol Rep
December 2024
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
This study conducts an in-depth review of the correlation between testis tissue changes and circulating microRNAs (miRNA) in diabetes-induced male reproductive complications, drawing upon both animal and clinical studies. The original articles published in English that specifically investigate miRNAs linked to male infertility in humans or animals with either type I or ΙΙ diabetes mellitus were included. The relevant articles were gathered from the PubMed, Google Scholar, Cochrane Library, and ScienceDirect databases.
View Article and Find Full Text PDFTrop Anim Health Prod
December 2024
Animal Nutrition Laboratory, Department of Animal Production and Health, School of Agriculture and Agricultural Technology, The Federal University of Technology Akure, P.M.B. 704, Akure, Nigeria.
To assess the ameliorative effects of wireweed leaf supplement (WLS) and ascorbate on reproductive potentials and gonadal oxidative status of cocks fed aflatoxin B1 (AFB1) contaminated diets, a total of 250 sexually mature cocks were distributed into five treatment groups: 1 (Control/Basal diet), 2 (Basal + 1 mg/kg AFB1), 3 (Basal + 1 mg/kg AFB1 + 200 mg/kg Ascorbate), 4 (Basal + 1 mg/kg AFB1 + 2.50 g/kg WLS) and 5 (Basal + 1 mg/kg AFB1 + 5.00 g/kg WLS).
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