Though not exempt from adverse events, azathioprine (AZA) is an inexpensive and effective drug in the induction and maintenance treatment of patients with inflammatory bowel disease. We present the case of a 20-year-old female patient with left-side ulcerative colitis in whom AZA was started at a dose of 1.5 mg/kg/day due to dependence on corticoids (thiopurine methyltransferase activity: 14.9 U/mL). Two weeks after starting treatment she began to report excessive hair loss, resulting in an almost complete loss of scalp hair.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.17235/reed.2021.8175/2021 | DOI Listing |
Front Pharmacol
May 2023
Department of Pharmacy, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Skinmed
July 2022
Department of Dermatology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Rev Esp Enferm Dig
January 2022
UGC Aparato Digestivo, Hospital de Poniente.
Though not exempt from adverse events, azathioprine (AZA) is an inexpensive and effective drug in the induction and maintenance treatment of patients with inflammatory bowel disease. We present the case of a 20-year-old female patient with left-side ulcerative colitis in whom AZA was started at a dose of 1.5 mg/kg/day due to dependence on corticoids (thiopurine methyltransferase activity: 14.
View Article and Find Full Text PDFThis report highlights azathioprine-induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.
View Article and Find Full Text PDFTransplant Proc
December 2018
Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan. Electronic address:
Background: Azathioprine (AZA) is the drug recommended for the continuation of immunosuppressive treatment after renal transplant in women during pregnancy.
Case Report: A 37-year-old Japanese female developed agranulocytosis and severe alopecia after initiation of AZA (50 mg), used as an alternative to mycophenolate mofetil (MMF, 1000 mg) therapy in anticipation of a planned pregnancy. Within 4 days of the initiation of AZA therapy, the patient developed a high fever, leucopenia, and cranial alopecia.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!