AI Article Synopsis
- Fluorinated drugs are increasingly popular in the pharmaceutical market, and this study focuses on using advanced F magic-angle spinning nuclear magnetic resonance (NMR) spectroscopy to analyze them.
- The technique allows for quick observation of fluorine signals with high-quality spectra obtained in just minutes, enabling efficient structural characterization of drugs like Celebrex, Cipro, and others.
- The study highlights how certain spectral features are sensitive to the type of fluorine present and the drug formulation, suggesting this method could greatly enhance the rapid analysis of fluorine-containing pharmaceuticals.
Article Abstract
Fluorinated drugs occupy a large and growing share of the pharmaceutical market. Here, we explore high-frequency, 60 to 111 kHz, F magic-angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy for the structural characterization of fluorinated active pharmaceutical ingredients in commercial formulations of seven blockbuster drugs: Celebrex, Cipro, Crestor, Levaquin, Lipitor, Prozac, and Zyvox. F signals can be observed in a single scan, and spectra with high signal-to-noise ratios can be acquired in minutes. F spectral parameters, such as chemical shifts and line widths, are sensitive to both the nature of the fluorine moiety and the formulation. We anticipate that the fast F MAS NMR-based approach presented here will be valuable for the rapid analysis of fluorine-containing drugs in a wide variety of formulations.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280463 | PMC |
| http://dx.doi.org/10.1021/acs.analchem.1c02917 | DOI Listing |
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