Characteristics and management of asymptomatic SARS-CoV-2 infections.

J Basic Clin Physiol Pharmacol

Department of Internal Medicine, Division of General Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Published: September 2021

AI Article Synopsis

  • - The COVID-19 pandemic has led to significant health challenges and societal impacts, with the disease presenting a wide range of symptoms, from no symptoms at all to severe cases resulting in death.
  • - Asymptomatic individuals can still spread the virus (SARS-CoV-2), having notable viral loads, but there are no approved antiviral treatments for them, making monitoring and strict infection control essential for management.
  • - Effective response strategies include thorough testing, contact tracing, quarantine, and vaccination, which is crucial for breaking the chains of transmission and ensuring community protection.

Article Abstract

The coronavirus disease 2019 (COVID-19) pandemic has caused and is still causing tremendous morbidity, mortality, and damage to our societies. The disease course of COVID-19 can be unpredictable ranging from asymptomatic infections to multi-organ failure and death. Transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from an asymptomatic infected individual to others has been observed early in the pandemic. Asymptomatic individuals have been shown to have quantitative SARS-CoV-2 viral loads, there may or may not be radiological and/or laboratory abnormalities. No antiviral therapy has been approved for the treatment of asymptomatic SARS-CoV2- infection. The management of asymptomatic individuals at home requires that the person can be monitored for any signs and symptoms of deterioration and that the requirements for infection prevention and control measures can be fulfilled. It is crucial to properly diagnose and manage asymptomatic COVID-19 cases with effective testing, contact tracing, quarantine, and isolation strategies. Preventing asymptomatic SARS-CoV-2 infections that have a major role in the unhindered transmission of the virus is a milestone to take control of the pandemic. Vaccination has been proven to be the crucial pillar for preventing asymptomatic infections and real-life data will continue to exhibit the effects of community vaccination in breaking the transmission chain of SARS-CoV-2 infections.

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Source
http://dx.doi.org/10.1515/jbcpp-2021-0159DOI Listing

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