AI Article Synopsis
- SERS is a cutting-edge technique for analyzing biofluids, showcasing four main experimental protocols that target purine metabolites and proteins.
- SERS methods demonstrate how concentrations of certain metabolites and proteins can indicate health conditions like cellular turnover, inflammation, and oxidative stress, which are affected by various diseases.
- The review emphasizes the need for further research to adapt SERS methods for practical clinical use, based on promising results from recent studies.
Article Abstract
Surface-enhanced Raman scattering (SERS) is emerging as a novel strategy for biofluid analysis. In this review, we delineate four experimental SERS protocols that are frequently used for the profiling of biofluids: 1) liquid SERS for the detection of purine metabolites; 2) iodide-modified liquid SERS for the detection of proteins; 3) dried SERS for the detection of both purine metabolites and proteins; 4) resonant Raman for the detection of carotenoids. To explain the selectivity of each experimental SERS protocol, we introduce a heuristic model for the chemisorption of analytes mediated by adsorbed ions (adions) onto the SERS substrate. Next, we show that the promising results of SERS liquid biopsy stem from the fact that the concentration levels of purine metabolites, proteins and carotenoids are informative of the cellular turnover rate, inflammation, and oxidative stress, respectively. These processes are perturbed in virtually every disease, from cancer to autoimmune maladies. Finally, we review recent SERS liquid biopsy studies and discuss future steps that are required for translating SERS in the clinical setting.
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| http://dx.doi.org/10.1016/j.colsurfb.2021.112064 | DOI Listing |
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