AI Article Synopsis
- The study aimed to explore the link between urinary incontinence (UI) in women and specific genetic polymorphisms related to serotonin and beta-adrenergic receptors.
- It involved 110 women with different types of UI and a control group of 105 healthy women, assessing their symptoms through a questionnaire and blood samples for genotyping.
- The findings revealed that the T102C gene polymorphism was significantly associated with Urge UI, suggesting it may increase the risk for this type of incontinence, while the Trp64Arg gene polymorphism showed no significant difference between the groups.
Article Abstract
Aim of study was set to investigate the association of women urinary incontinence (UI) with serotonin receptor T102C and beta 3-adrenergic receptor Trp64Arg genes polymorphisms. The study included 110 women with Urge, Stress, and Mixed UI types and the control group - 105 continent women. Both groups have filled in the ICIQ-FLUTS questionnaire and their blood genotyping was performed. Urge UI subgroup was older and had higher body mass index (BMI) in comparison to other UI types and control group. More than half of all women had family history of UI in Stress UI and Mixed UI subgroups. The frequency of T102C gene polymorphism's minor allele C and genotype CC was significantly more expressed in Urge UI subgroup, as compared with control group (C-77.3 vs 58.7%, = 0.007 and CC-57.6 vs 31.1%, = 0.015). The Trp64Arg gene polymorphism did not differ between groups. The regression analysis revealed CC genotype (OR = 3.06, 95% CI: 1.11-8.43; = 0.030) and allele C (OR = 2.53, 95% CI: 1.16-5.53; = 0.020) were risk factors for development of Urge UI. We conclude that T102C gene polymorphism affected the development of Urge UI.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389500 | PMC |
| http://dx.doi.org/10.1515/med-2021-0332 | DOI Listing |
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