AI Article Synopsis
- The advancements in medical imaging are transforming cancer diagnostics by emphasizing the importance of dual-modal imaging over single modality approaches.
- The rare earth element Holmium (Ho) shows promise as a nanoprobe due to its paramagnetic properties and ability to enhance X-ray imaging, making it suitable for combined CT and MRI scans.
- A new type of HoF nanoparticle (PEG-HoF NPs) has been developed, boasting good water solubility, low toxicity, and biocompatibility, signaling potential for broader applications in dual-modal imaging.
Article Abstract
The rapid development of medical imaging has boosted the abilities of modern medicine. As single modality imaging limits complex cancer diagnostics, dual-modal imaging has come into the spotlight in clinical settings. The rare earth element Holmium (Ho) has intrinsic paramagnetism and great X-ray attenuation due to its high atomic number. These features endow Ho with good potential to be a nanoprobe in combined x-ray computed tomography (CT) and T-weighted magnetic resonance imaging (MRI). Herein, we present a facile strategy for preparing HoF nanoparticles (HoF NPs) with modification by PEG 4000. The functional PEG-HoF NPs have good water solubility, low cytotoxicity, and biocompatibility as a dual-modal contrast agent. Currently, there is limited systematic and intensive investigation of Ho-based nanomaterials for dual-modal imaging. Our PEG-HoF NPs provide a new direction to realize and CT/MRI imaging, as well as validation of Ho-based nanomaterials will verify their potential for biomedical applications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427799 | PMC |
| http://dx.doi.org/10.3389/fonc.2021.741383 | DOI Listing |
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