Extra-pulmonary tuberculosis still remains an important differential diagnosis for chronic musculoskeletal ailments in developing countries like India and may involve any part of the body without characteristic systemic features. We are presenting a rare case of a four-year-old female child, who came to our tertiary-care hospital with chief complaints of pain in the left foot along with a gradually increasing swelling over the dorsum of the foot for the past five months. There was no history of trauma or constitutional symptoms. The serum inflammatory markers were found raised, and X-ray and magnetic resonance imaging revealed an isolated lytic lesion in the talus bone. Debridement, as well as curettage of the lesion, was done, both as a diagnostic and therapeutic procedure. A caseous cheesy material was evacuated and sent for microbiological and histopathological evaluation, which revealed the presence of acid-fast bacilli and granulomatous lesion confirming the diagnosis of tuberculosis. The patient was started with anti-tubercular chemotherapy, which continued for a total duration of 14 months, along with foot and ankle immobilization in a below-knee cast for three months. After completion of therapy, there was complete resolution of the lytic lesion on x-ray, with full symptom relief, and a full range of movement of the ankle was obtained. In cases with longstanding pain and swelling of the foot, with or without associated systemic symptoms, tuberculosis should be considered as a strong differential diagnosis even in young children, especially in developing countries. Diagnostic and therapeutic curettage along with anti-tubercular chemotherapy can result in a good functional outcome in such patients.
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http://dx.doi.org/10.7759/cureus.16909 | DOI Listing |
Cureus
November 2024
Neurosurgery, University of Illinois College of Medicine Peoria, Peoria, USA.
Petroclival approaches remain challenging given abundant cranial nerves and vessels. Common trajectories include transsphenoidal, transoral, middle fossa-extradural, and posterior through the cerebellar peduncle. We report a unique intra-axial, intradural approach to the petroclival and cavernous sinus.
View Article and Find Full Text PDFOncologist
December 2024
Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, United States.
Background: Sarcomatoid carcinomas (SC) are rare tumors with both epithelial and mesenchymal characteristics, linked to aggressive behavior and poor prognosis. Sarcomatoid carcinoma of unknown primary (SCUP) is an exceedingly rare subset with limited literature and no standardized management guidelines. This study aims to characterize the clinical presentations, treatment patterns, and genomic landscape of SCUP.
View Article and Find Full Text PDFRadiol Case Rep
February 2025
Rheumatology Department, University Hospital Son Llátzer, Mallorca, Spain.
Osseous sarcoidosis is a rare manifestation of sarcoidosis, often mimicking other conditions like metastatic disease. Skeletal involvement occurs in only 3%-13% of cases (1), making diagnosis challenging. We present the case of a 63-year-old female with a 1-month history of inflammatory bone pain and multiple lytic and blastic lesions.
View Article and Find Full Text PDFJ Neurosurg Case Lessons
December 2024
Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi.
Background: The authors describe the case of a 35-year-old male who presented with back pain and painful masses on his upper extremities. He had a known sacral lesion identified 1 year prior at an outside facility, suspected to be coccidioidomycosis on biopsy, but the workup was not completed because the patient left against medical advice and was lost to follow-up. Computed tomography (CT) and magnetic resonance imaging revealed lytic destructive lesions involving the calvaria, thoracolumbar spine, and sacrum, concerning for an active and disseminated infection.
View Article and Find Full Text PDFSkeletal Radiol
December 2024
Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
The case report discusses xanthogranulomatous osteomyelitis, a rare inflammatory bone condition that can resemble malignancy on imaging studies. The report details a case of a 42-year-old woman with left leg pain, swelling, and redness lasting 4 months. Imaging revealed a lytic lesion in the left tibia with endosteal erosion, and MRI showed extraosseous soft tissue extension.
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