Ganglioneuromas are rare, benign tumors arising from the sympathetic nervous system. The presentation of the tumor is variable and may be associated with scoliosis. Few reports of ganglioneuroma associated with scoliosis- exist and most involve the thoracic spine. Here, we present a 13-year-old female with scoliosis who was found to have a lumbar ganglioneuroma. The patient was treated with a subtotal resection and lumbar spinal fusion to correct her scoliosis in a single-stage operation. The patient's symptoms and scoliosis markedly improved following treatment without any complications. Additionally, we conducted an up-to-date literature review of ganglioneuromas associated with scoliosis that have been published in the last 20 years. We discuss variations in clinical presentation and surgical approach.
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| http://dx.doi.org/10.7759/cureus.16794 | DOI Listing |
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- Spinal ganglioneuromas are rare neuroblastic tumors mostly found in children, originating from sympathetic ganglia near the spine, and can lead to radicular or medullary symptoms when they extend into the spinal canal.
- A thorough review of pediatric cases was conducted, highlighting a unique case treated in France, focusing on the thoraco-lumbar region due to its different surgical management requirements.
- The review identified 21 pediatric patients, predominantly females, with the majority (42.85%) of tumors located in the thoracic spine, while the featured case presented unusual symptoms including abdominal pain and renal complications.
Background: Ganglioneuroma (GN) is a rare, benign tumor that originates from neural crest cells and can potentially affect any anatomical site within the sympathetic nervous system. Typically, GNs are more frequently reported in children and young adults, with a slightly higher prevalence in females. We are reporting a rare case of a giant lumbar spine ganglioneuroma by outlining the clinical presentation, radiological finding, management, and outcome.
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Objective: Spinal ganglioneuromas (GNs) are rare benign tumors that often manifest as symptoms related to the compression of neural elements. The preferred treatment for affected patients is surgical resection, which typically improves symptoms and accompanies a low likelihood of tumor recurrence. We conducted a systematic review of reports of GNs involving the spinal cord and nerve roots, examining their clinical presentation, surgical management, and outcomes.
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1Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
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