Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jcf.2021.08.032 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
IRE1 is a Promising Therapeutic Target in Pancreatic Cancer.
Am J Physiol Cell Physiol
January 2025
Department of General, Visceral, and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Pancreatic cancer (PC) is one of the most aggressive malignancies, characterized by an increasing incidence and unfavorable prognosis. Despite recent advances, surgical resection combined with chemotherapy remains the only potentially curative therapeutic option. Therefore, it is of paramount importance to identify novel therapeutic targets and develop effective treatment strategies.
View Article and Find Full Text PDFBradykinin attenuates NiSO-induced autophagy in MIN6 cells and protects islet function in mice by regulating the PI3K/AKT/mTOR signaling pathway.
Biochem Biophys Res Commun
February 2025
Department of Endocrinology and Metabolism, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, People's Republic of China; The Second Clinical Medical College, Lanzhou University, Lanzhou, People's Republic of China. Electronic address:
Previous studies have shown that nickel sulfate (NiSO) increases autophagy in thyroid cells and tissues. As an important organ of the endocrine system, the pancreas not only contributes to the exocrine function of digestion but also has the endocrine function of regulating blood sugar. However, it remains unknown whether NiSO increases pancreatic autophagy.
View Article and Find Full Text PDFUSP18-mediated protein stabilization of NOTCH1 is associated with altered Th17/Treg cell ratios and B cell-mediated autoantibody secretion in Sjögren syndrome.
Immunol Res
December 2024
Department of Rheumatism and Immunology, Seventh Medical Center of Chinese PLA General Hospital, No. 5, Nanmencang, Dongcheng District, Beijing, 100700, P.R. China.
Sjögren Syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of exocrine glands. This study, based on bioinformatics predictions, investigates the biological functions of ubiquitin specific peptidase 18 (USP18) and notch receptor 1 (NOTCH1) in T helper 17 (Th17) and regulatory T (Treg) cell imbalance and B cell activity in SS. USP18 and NOTCH1 were highly expressed in peripheral blood mononuclear cells (PBMCs) of SS patients and the PBMCs of NOD mice compared to the controls.
View Article and Find Full Text PDFREsolution of Symptoms afTer Oesophago-gastric cancer REsection delphi (RESTOREd)-standardizing the definition, investigation and management of gastrointestinal symptoms and conditions after surgery.
Br J Surg
November 2024
Department of Gastroenterology, United Lincolnshire Hospitals NHS Trust, Lincoln, UK.
Background: Oesophago-gastric cancer surgery negatively affects quality of life with a high postoperative symptom burden. Several conditions that may be diagnosed and treated after surgery are recognised. However, consensus regarding their definition and management is lacking.
View Article and Find Full Text PDFPossible inhibition effects of resveratrol on pancreatic tumorigenesis in the azaserine-rat model.
APMIS
January 2025
General Surgery Department, Private Kayseri Acibadem Hospital, Kayseri, Turkey.
Resveratrol, which is thought to have a preventive effect on the formation of different types of cancer, is abundant in grapes and other foods. Resveratrol has been shown to have anti-cancer effects by in vitro andin vivo studies, however this is the first time its effect on atypical acinar cell foci (AACF), known as precursor forms of pancreatic carcinoma, has been experimentally investigated. Male Sprague Dawley rats, each consisting of 5 experimental groups (Cont, AzCont, AzRes10, AzRes15, and AzRes20), 10 of which were 14 days old, were used in the study.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!