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An injectable biomimetic hydrogel adapting brain tissue mechanical strength for postoperative treatment of glioblastoma without anti-tumor drugs participation.
J Control Release
September 2024
College of Biomedical Engineering and National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Electronic address:
Adapting the mechanical strength between the implant materials and the brain tissue is crucial for the postoperative treatment of glioblastoma. However, no related study has been reported. Herein, we report an injectable lipoic acid‑iron (LA-Fe) hydrogel (LFH) that can adapt to the mechanical strength of various brain tissues, including human brain tissue, by coordinating Fe into a hybrid hydrogel of LA and its sodium salt (LANa).
View Article and Find Full Text PDFImmunohistochemical Expression of PTEN in Canine Gliomas.
Animals (Basel)
July 2024
Unitat de Patologia Murina i Comparada, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
Phosphatase and tensin homolog (PTEN) is a critical tumor suppressor gene with a vital role in regulating cell proliferation, migration, and survival. The loss of PTEN function, either by genetic alterations or decreased protein expression, is frequent in human gliomas and has been correlated with tumor progression, grade, therapeutic resistance, and decreased overall survival in patients with glioma. While different genetic mutations in PTEN gene have been occasionally reported in canine gliomas, no alterations in protein expression have been reported.
View Article and Find Full Text PDFA syngeneic spontaneous zebrafish model of -deficient, EGFR, and PI3KCA-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo.
Elife
July 2024
Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada.
High-throughput vertebrate animal model systems for the study of patient-specific biology and new therapeutic approaches for aggressive brain tumors are currently lacking, and new approaches are urgently needed. Therefore, to build a patient-relevant in vivo model of human glioblastoma, we expressed common oncogenic variants including activated human EGFR and PI3KCA under the control of the radial glial-specific promoter in syngeneic loss-of-function mutant zebrafish. Robust tumor formation was observed prior to 45 days of life, and tumors had a gene expression signature similar to human glioblastoma of the mesenchymal subtype, with a strong inflammatory component.
View Article and Find Full Text PDFInhibition of PERK-mediated unfolded protein response acts as a switch for reversal of residual senescence and as senolytic therapy in glioblastoma.
Neuro Oncol
November 2024
Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400094, India.
Background: Glioblastoma due to recurrence is clinically challenging with 10-15 months overall survival. Previously we showed that therapy-induced senescence (TIS) in glioblastoma reverses causing recurrence. Here, we aim to delineate the TIS reversal mechanism for potential therapeutic intervention to prevent glioblastoma (GBM) recurrence.
View Article and Find Full Text PDFA Critical Role of Culture Medium Selection in Maximizing the Purity and Expansion of Natural Killer Cells.
Cells
July 2024
Department of Cell Biology, Bielefeld University, 33615 Bielefeld, Germany.
Natural killer (NK) cells hold promise in cancer treatment due to their ability to spontaneously lyse cancer cells. For clinical use, high quantities of pure, functional NK cells are necessary. Combining adherence-based isolation with specialized media showed the unreliability of the isolation method, but demonstrated the superiority of the NK MACS medium, particularly in suboptimal conditions.
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