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The influence of positive and negative intraoperative feedback in laparoscopic simulation in pediatric urology training.
J Pediatr Urol
January 2025
Department of Pediatric Surgery and Urology, National Reference Center for Rare Urinary Tract Malformations (CRMR MARVU), ERN eUROGEN Accredited Center, Robert-Debré University Hospital, APHP, GHU North, Health Simulation Department, iLumens, Université Paris Cité, Paris, France; UMR INSERM 1141 NEURODEV, Paris, France. Electronic address:
Background And Objective: This study aimed to explore the impact of positive or negative feedback on the performance of trainees in pediatric urology during simulation exercises in pediatric laparoscopy.
Methods: Twenty-five students enrolled in a national Pediatric Urology Laparoscopy Simulation participated in the study. They performed the Fundamentals of Laparoscopic Surgery (FLS) skills, specifically peg-transfer and intracorporeal knot-tying, in a randomized study design while receiving positive or negative feedback from an attending pediatric urologist.
Social prescribing for adults with chronic pain in the U.K.: a rapid review.
Br J Pain
January 2025
Centre for Pain Research, School of Health, Leeds Beckett University, Leeds, UK.
Introduction: Social prescribing links patients to community groups and services to meet health needs; however, it is uncertain what the benefits and impacts of social prescribing are for people with chronic pain. The National Institute for Health and Care Excellence (NICE) undertook a systematic review to investigate the clinical and cost effectiveness of social interventions aimed at improving the quality of life of people with chronic pain; no relevant clinical studies comparing social interventions with standard care for chronic pain were found, though the inclusion criteria for studies was narrow.
Objectives: To undertake a rapid review of all types of research and policy on social prescribing for adults with chronic pain in the U.
Health State Utility Values in Fabry Disease: Insights from the Pegunigalsidase Alfa Clinical Trials.
Adv Ther
January 2025
Cytel, Inc., Waltham, MA, USA.
Introduction: Fabry disease (FD) is a rare lysosomal storage disorder that is associated with pain and progressive damage to the renal, cardiac, and cerebrovascular systems. Enzyme replacement therapy (ERT) is one of the treatment options for FD and the most recently approved ERT agent, pegunigalsidase alfa, has shown clinical efficacy in three phase 3 clinical trials of adults with FD: BALANCE, BRIDGE, and BRIGHT. Recent published guidelines support the mapping of health utility state data to the EuroQol-5 Dimension-3 Level (EQ-5D-3L) index to align with the preferred methodology used by the National Institute for Health and Care Excellence (NICE).
View Article and Find Full Text PDFDoes climate policy uncertainty shape the response of stock markets to oil price changes? Evidence from GCC stock markets.
J Environ Manage
January 2025
Université Clermont Auvergne, CleRMa, 11 bd Charles de Gaulle, 63000, Clermont-Ferrand, France. Electronic address:
This paper investigates how climate policy uncertainty (CPU) drives the sensitivity of Gulf Cooperation Council (GCC) countries' stock markets to oil price changes. Based on a sample of monthly observations from 2008 to 2022, it appears that CPU negatively moderates the link between lagged oil price changes and subsequent GCC stock market returns. Interestingly, the impact of CPU on the oil-stock relationship is non-linear.
View Article and Find Full Text PDFCholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer.
Nat Immunol
January 2025
Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Maturation of conventional dendritic cells (cDCs) is crucial for maintaining tolerogenic safeguards against auto-immunity and for promoting immunogenic responses to pathogens and cancer. The subcellular mechanism for cDC maturation remains poorly defined. We show that cDCs mature by leveraging an internal reservoir of cholesterol (harnessed from extracellular cell debris and generated by de novo synthesis) to assemble lipid nanodomains on cell surfaces of maturing cDCs, enhance expression of maturation markers and stabilize immune receptor signaling.
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