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Advances in protein subunit vaccines against H1N1/09 influenza.
Front Immunol
December 2024
Department of Immunology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, China.
The A/H1N1pdm09 influenza virus, which caused the 2009 pandemic, has since become a recurring strain in seasonal influenza outbreaks. Given the ongoing threat of influenza, protein subunit vaccines have garnered significant attention for their safety and effectiveness. This review seeks to highlight the latest developments in protein subunit vaccines that specifically target the A/H1N1pdm09 virus.
View Article and Find Full Text PDFNS1 and PA-X of H1N1/09 influenza virus act in a concerted manner to manipulate the innate immune response of porcine respiratory epithelial cells.
Front Cell Infect Microbiol
July 2023
Institute of Virology and Immunology, Mittelhäusern, Switzerland.
Live-attenuated influenza A viruses (LAIV) may be superior to inactivated or subunit vaccines since they can be administered via mucosal routes to induce local immunity in the respiratory tract. In addition, LAIV are expected to trigger stronger T-cell responses that may protect against a broader range of antigen-drifted viruses. However, the development of LAIV is challenging since a proper balance between immunogenicity and safety has to be reached.
View Article and Find Full Text PDFEpidemiology and Outcomes of HIN1 Pneumonia in ICU.
Indian J Crit Care Med
July 2023
Department of Critical Care Medicine, Apollo Specialty Hospitals, Chennai, Tamil Nadu, India.
Introduction: Pandemic influenza H1N1/09 emerged for the first time in April 2009 and has spread widely across India since then. The number of cases have increased over time with the increasing need for respiratory support, causing significant morbidity and mortality. We evaluated the clinical course and outcomes of patients infected with Influenza A (H1N1) admitted to three multidisciplinary intensive care units (ICU) in Chennai.
View Article and Find Full Text PDFtranscription is an early predictor for COVID-19 outcomes, a multi-cohort observational study.
Front Immunol
January 2023
Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia.
Purpose: Robust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate biomarkers have been proposed for COVID-19. However, at present, there is no consensus on the best diagnostic approach to predict outcomes in infected patients.
View Article and Find Full Text PDFTropism and Infectivity of Pandemic Influenza A H1N1/09 Virus in the Human Placenta.
Viruses
December 2022
Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, China.
Influenza virus infection in pregnant women may put the fetus at higher risk; however, to date, there has been no detailed research about the expression of influenza virus receptors in the human placenta. We employed the lectin staining technique, which is a classic influenza virus receptor research method for studying the distribution of viral receptors in the human placenta. In addition, we examined the susceptibility of the human placenta to H1N1/09, by detecting viral proteins and RNA at different time points post-infection.
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