AI Article Synopsis
- Serum growth differentiation factor 15 (GDF15) is an important biomarker for detecting mitochondrial diseases, but its significance in newborns is not well studied.
- Blood samples from 18 newborns showed that GDF15 levels dropped to about 35% of their initial cord blood levels within the first week of life.
- The study found that GDF15 levels negatively correlated with postnatal age and birth weight but positively correlated with levels of other molecules like N-terminal pro-brain natriuretic peptide and lactate, suggesting GDF15 could indicate the newborn's shift to aerobic metabolism.
Article Abstract
Serum growth differentiation factor 15 (GDF15) is a useful biomarker of mitochondrial diseases; its utility in newborns remains unknown. To investigate the temporal change in GDF15 within the first week of life, and to identify its potential control variables, blood samples were obtained from 18 newborns. The GDF15 levels declined to approximately 35% of the cord blood levels within the first week of life and were negatively correlated with postnatal age and Z-score of birth weight but were positively correlated with N-terminal pro-brain natriuretic peptide and lactate levels. GDF15 levels may reflect the progress of postnatal transition to aerobic metabolism.
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| http://dx.doi.org/10.1016/j.mito.2021.09.002 | DOI Listing |
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