AI Article Synopsis
- The study aimed to assess how well adult celiac patients adhere to a gluten-free diet two decades after being diagnosed, primarily focusing on those diagnosed during childhood through mass screening.
- Researchers conducted phone interviews with two groups: one diagnosed via screening and another diagnosed due to symptoms, measuring their diet adherence with a specific questionnaire.
- Results showed that while a significant number of patients maintained good adherence to the diet, about half of those diagnosed through screening did not meet optimal diet criteria, and several patients developed additional autoimmune diseases over the years.
Article Abstract
Objectives: To investigate the compliance to the gluten-free diet in a cohort of adult celiac patients 20 years after the diagnosis, received in childhood through a mass screening.
Methods: This is an observational historic cohort follow-up study. It was carried out at the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. Two matched cohorts of adult celiac patients, diagnosed in childhood through a mass screening or for symptoms were enrolled. Adherence to the gluten free-diet and development of autoimmune diseases were investigated through a questionnaire administrated in the course of a phone interview.The primary study outcome was the adherence to the gluten-free diet, measured through the Biagi questionnaire, in the two cohorts of celiac patients.
Results: We contacted 25 patients (mean age 28 years, 19 females) diagnosed with screening and 34 patients (mean age 25 years, 26 females) diagnosed in the same period for symptoms. After 20 years, in the cohort diagnosed with screening and in the cohort diagnosed for symptoms the adherence to the gluten-free diet was optimal in 14 (56%) and 26 (81%), improvable in 5 (20%) and 3 (9%), inadequate in 6 (24%) and 3 (9%), respectively. In the two cohorts, four patients (16%) and six patients (18%) developed other autoimmune diseases.
Conclusions: Twenty years after the diagnosis, near half of the patients diagnosed in a mass screening, does not have an optimal adherence to the gluten-free diet and a remarkable proportion of them have developed another autoimmune disease.
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| http://dx.doi.org/10.1097/MPG.0000000000003295 | DOI Listing |
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