Objective: To analyse determinants of mortality at 15years in a population over 60years of age and physically active.
Methods: This is a prospective longitudinal study. After 15years of participating in an active aging programme, participants were contacted by telephone to verify their state of health and to determine whether in that time they had had any fractures.
Results: A total of 561 individuals over 60years of age were included, 82% of whom were women. Only differences in densitometric data, FRAX values and history of previous fracture at baseline characteristics were found between the group that died at 15years and the group that remained alive. The only variables that were related to mortality risk were the basal data of the densitometric T-score (OR=.50, P<.001) and history of fracture in any location (OR=2.44, P<.033).
Conclusions: The value of bone mineral density could be considered as a useful biomarker to calculate the risk of mortality in people over 60years old with a physically active lifestyle.
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http://dx.doi.org/10.1016/j.reuma.2021.07.003 | DOI Listing |
Cureus
November 2024
Pharmacovigilance, Regional Training Center and ADR (Adverse Drug Reaction) Monitoring Center, Amrita Institute of Medical Science, Amrita Vishwa Vidyapeetham, Ernakulam, IND.
Objective: This study aimed to analyze the pattern, severity, and outcomes of adverse drug reactions (ADRs) associated with rituximab use reported to a regional pharmacovigilance center in Kerala, India.
Methods: This retrospective study analyzed rituximab-associated ADRs reported from 2017 to 2023. ADRs were assessed using the WHO-UMC criteria for causality and the Modified Hartwig Siegel Scale for severity.
Ann Neurol
December 2024
Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Objective: Remote identification of individuals with severe hyposmia may enable scalable recruitment of participants with underlying alpha-synuclein aggregation. We evaluated the performance of a staged screening paradigm using remote smell testing to enrich for abnormal dopamine transporter single-photon emission computed tomography imaging (DAT-SPECT) and alpha-synuclein aggregation.
Methods: The Parkinson's Progression Markers Initiative (PPMI) recruited participants for the prodromal cohort who were 60-years and older without a Parkinson's disease diagnosis.
Am J Cardiol
December 2024
Department of Cardiovascular Medicine, Phoenix, Arizona.
Aneurysms are often associated with connective tissue disorders, but most occur sporadically and are nonsyndromic. Manifestations of these nonsyndromic arteriopathies across genders and age groups have not been discussed extensively in previous studies, especially in younger cohorts. We analyzed data from 84,496 patients in the Mayo Clinic Tapestry DNA Sequencing Study, excluding those with known vascular syndromes.
View Article and Find Full Text PDFSkeletal Radiol
December 2024
Department of Rheumatology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Objective: MRI of the hands is valuable for risk-stratification in patients with arthralgia at-risk for developing rheumatoid arthritis (RA). Contrast-enhanced MRI is considered standard for assessment of RA, but has practical disadvantages. It also shows inflammation-like features in the general population, especially at older age, which should be considered in image interpretation.
View Article and Find Full Text PDFBraz J Infect Dis
November 2024
Secretaria Estadual de Saúde do Espírito Santo, Vitória, ES, Brazil.
Introduction: Community-Acquired Pneumonia (CAP) caused by pneumococcus and Invasive Pneumococcal Disease (IPD) pose a substantial economic burden on health systems. The objective of the present study is to explore hospitalization costs of pneumococcal disease in the public health system in Brazil, the Unified Health System.
Methods: Retrospective analysis of administrative data on hospitalized cases of pneumococcal disease from January 2019 to July 2023.
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