Microbial transformation is an important tool to perform selective conversion of compounds to derivatives which are difficult to produce synthetically. In order to obtain icariside II and icaritin, the active components in Herba Epimedii , biotransformation studies using microbes as biocatalysts were carried out. Icariside II () and icaritin () were produced through biotransformation of icariin () using the fungi and var. in 98% and 92% yields, respectively. In the subsequent transformation studies, was deglycosylated to form by , whereas was further converted to a novel compound icaritin-3--β-d-glucopyranoside () and previously known icaritin-3,7--β-d-diglucopyranoside () by . Biological evaluation of these compounds using MTT assay exhibited potent cytotoxic activities against human cancer cell lines A549, A375P, and MCF-7, with icariin being the most active, indicating that glycosylation plays a role in the cytotoxic activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2021.1975702 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Co-consumption for plastics upcycling: A perspective.
Metab Eng Commun
June 2025
Department of Chemical Engineering, University of Waterloo, Canada.
The growing plastics end-of-life crisis threatens ecosystems and human health globally. Microbial plastic degradation and upcycling have emerged as potential solutions to this complex challenge, but their industrial feasibility and limitations thereon have not been fully characterized. In this perspective paper, we review literature describing both plastic degradation and transformation of plastic monomers into value-added products by microbes.
View Article and Find Full Text PDFLipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes.
Commun Biol
January 2025
College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, China.
Hibernation is a necessary means for animals to maintain survival while coping with low temperatures and food shortages. While most studies have largely focused on mammalian hibernation, its reptilian equivalent has been less studied. In order to provide insights into the energy metabolism and potential microbial regulatory mechanisms in hibernating snakes, the serum, liver, gut content samples were measured by multi-omic methods.
View Article and Find Full Text PDFIron-carbon micro-electrolysis coupled to heterotrophic nitrification aerobic denitrification treating low carbon/nitrogen mariculture wastewater.
Environ Res
January 2025
Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, Nanjing, 210044, China. Electronic address:
Considering the unsatisfied nitrogen (N) and phosphorus (P) treatment performance of mariculture wastewater caused by low carbon/nitrogen (C/N), a novel iron-carbon (Fe-C) micro-electrolysis coupled to heterotrophic nitrification aerobic denitrification (HNAD) process was proposed to enhance the N and P elimination. Results revealed that total nitrogen (TN) removal and total phosphorus (TP) removal efficiencies in Fe-C filter with HNAD (R-Fe) increased by 76.1% and 113.
View Article and Find Full Text PDFShaping rhizocompartments and phyllosphere microbiomes and antibiotic resistance genes: The influence of different fertilizer regimes and biochar application.
J Hazard Mater
January 2025
Department of Biology, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, China; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Understanding the impact of different soil amendments on microbial communities and antibiotic resistance genes (ARGs) dissemination is crucial for optimizing agricultural practices and mitigating environmental risks. This study investigated the effects of different fertilizer regimes and biochar on plant-associated bacterial communities and ARGs dissemination. The biochar's structural and chemical characteristics were characterized using scanning electron microscopy (SEM) and Fourier-transform infrared (FTIR) spectroscopy, revealing a porous architecture with diverse functional groups.
View Article and Find Full Text PDFSynergistic Effects of NO/HS Gases on Antibacterial, Anti-inflammatory, and Analgesic Properties in Oral Ulcers Using a Gas-Releasing Nanoplatform.
Acta Biomater
January 2025
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, P. R. China. Electronic address:
Article Synopsis
- Oral mucosal wounds are susceptible to inflammation and complications due to exposure to microorganisms, which can hinder daily activities and diminish quality of life.
- A novel therapeutic nanoplatform, DATS@Arg-EA-SA, has been developed to target these wounds by combining guanidinated dendritic peptides with diallyl trisulfide (DATS), providing both antimicrobial and anti-inflammatory effects.
- This nanoplatform effectively eliminates various bacteria, including drug-resistant strains like MRSA, and enhances healing by promoting the transition of inflammatory cells and alleviating pain, making it a promising solution for oral wound treatment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!