AI Article Synopsis
- Understanding placental insufficiency is crucial for addressing issues like preeclampsia and fetal growth restriction.
- Dynamic contrast-enhanced MRI (DCE MRI) is a powerful tool for studying the placenta, allowing researchers to measure key microcirculatory parameters such as blood flow and permeability.
- For successful application in humans, safety of contrast agents during pregnancy must be confirmed, as their use is already established in animal models.
Article Abstract
It is important to develop a better understanding of placental insufficiency given its role in common maternofetal complications such as preeclampsia and fetal growth restriction. Functional magnetic resonance imaging offers unprecedented techniques for exploring the placenta under both normal and pathological physiological conditions. Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is an established and very robust method to investigate the microcirculatory parameters of an organ and more specifically its perfusion. It is currently a gold standard in the physiological and circulatory evaluation of an organ. Its application to the human placenta could enable to access many microcirculatory parameters relevant to the placental function such as organ blood flow, fractional blood volume, and permeability surface area, by the acquisition of serial images, before, during, and after administration of an intravenous contrast agent. Widely used in animal models with gadolinium-based contrast agents, its application to the human placenta could be possible if the safety of contrast agents in pregnancy is established or they are confirmed to not cross the placenta.
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| http://dx.doi.org/10.1016/j.placenta.2021.08.055 | DOI Listing |
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