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Macronutrients in Human Milk Exposed to Antidepressant and Anti-Inflammatory Medications.
JAMA Netw Open
January 2025
Department of Pediatrics, Center for Better Beginnings, University of California, San Diego, La Jolla.
Importance: The association between maternal medications and the macronutrient composition of human milk has not been studied.
Objective: To compare macronutrient levels in milk samples from mothers treated with long-term medications with samples from untreated healthy and disease-matched control mothers (DMCs).
Design, Setting, And Participants: A cross-sectional study using samples collected between October 2014 and January 2024 from breastfeeding mothers in the US and Canada invited to participate to the Mommy's Milk Human Milk Research Biorepository at the University of California, San Diego.
The Association Between Maternal Psychological Health and Human Milk Oligosaccharide Composition.
Breastfeed Med
November 2024
Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.
Human milk oligosaccharides (HMOs) are carbohydrates abundant in human breast milk. Their composition varies widely among women, and prior research has identified numerous factors contributing to this variation. However, the relationship between maternal psychological health and HMO levels is currently unknown.
View Article and Find Full Text PDFMommy's microbes: Gestational diabetes mellitus shapes the maternal and infant gut microbiome.
Cell Host Microbe
July 2024
Goodman-Luskin Microbiome Center, University of California Los Angeles, Los Angeles, CA, USA; The Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Division of Gastroenterology, Hepatology and Parenteral Nutrition, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA. Electronic address:
Gestational diabetes mellitus (GDM) is associated with increased risk of metabolic and neurodevelopmental disorders in offspring. In this issue of Cell Host & Microbe, Wang et al. provide evidence that changes in the gut microbiome of mothers with GDM may lead to dysbiosis in their infants and altered development in a sex-dependent manner.
View Article and Find Full Text PDFConsistency and Variability of the Human Milk Oligosaccharide Profile in Repeat Pregnancies.
Nutrients
February 2024
Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Human milk oligosaccharides (HMOs) are a set of complex carbohydrates and the third largest solid component of human milk, after lactose and lipids. To date, over 150 HMOs have been identified and the diversity of structures produced by lactating women is influenced by maternal genetics as well as other maternal, infant, and environmental factors. While the concentrations of individual HMOs have been shown to vary between individuals and throughout the course of lactation, the variability of HMO concentration profiles following different pregnancies occurring in the same woman is presently unknown.
View Article and Find Full Text PDFBackground: Vitamin B12 and folate are essential micronutrients important for normal infant growth and development.
Objectives: The aims were to describe vitamin B12 and folate status in pregnant females and their infants according to commonly used status cutoffs and examine the associations between maternal status, maternal supplement use, and breastfeeding and infant status.
Methods: Pregnant females were recruited at 18 wk gestation in Bergen, Norway.
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