AI Article Synopsis
- This study investigates the prevalence of elevated D-dimer levels in confirmed COVID-19 patients in the ICU of a hospital in western Nepal, finding significant levels of the marker related to hemostatic abnormalities.
- Out of 95 patients analyzed, a high percentage of both older (89.3%) and younger patients (62.69%) presented with elevated D-dimer upon admission, with 67.4% of those with elevated levels experiencing mortality.
- The results suggest that measuring D-dimer levels can be an important factor in clinical decision-making for COVID-19 patients, particularly in critical care settings.
Article Abstract
Introduction: D-dimer is currently the best available marker for COVID-19 associated hemostatic abnormalities. This study aims to find out the prevelance of elevated D-dimer levels in confirmed COVID-19 cases in intensive care unit of a tertiary care hospital of western Nepal.
Methods: This descriptive cross-sectional study was conducted among 95 patients admitted to COVID Intensive Care Unit of a teriary care centre from August 2020 to January 2021 after taking ethical clearence from Institutional Review Committee in order to determine the D-dimer levels in confirmed COVID-19 cases. D-dimer value was measured at the admission and the highest D-dimer value was recorded during the course of hospital stay with the risk of mortality in confirmed COVID-19 cases. The normal range of D-dimer was taken as <0.35 mg/dl as per our hospital laboratory standards. Convenience sampling method was used. Data entry and descriptive analysis were done in Statistical Package for the Social Sciences version 25.0, point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data.
Results: Out of total 95 cases of COVID-19 included in this study, 25 (89.3%) patients with age ≥ 65 years and 42 (62.69%) patients aged <65 years had elevated D-dimer on admission. Data showed that 29 (67.4%) patients having elevated D-dimer at admission had mortality.
Conclusions: Elevated D-dimer levels was frequently seen in patients admitted in Intensive Care Unit with COVID-19. Our study suggested that measurement of D-dimer may guide in clinical decision making.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369534 | PMC |
| http://dx.doi.org/10.31729/jnma.6284 | DOI Listing |
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