Introduction: This review aims to present the current state of knowledge about attachment and obsessive-compulsive disorder (OCD), the connection to the disorder's course, and the treatment effectiveness.
Method: A literature search was performed using PubMed, Google Scholar, Web of Science, and ScienceDirect databases using the following search terms: obsessive compulsive disorder, attachment, therapy, treatment, and long-term outcome. The period of extraction was between January 1990 and October 2020.
Results: Insecure attachment leads to the formation of dysfunctional beliefs about the world and self, which influences the dynamics of OCD. It is associated with maladaptive cognitive processes such as an inflated sense of responsibility, perfectionism, and mind control. With worse emotional regulation and reduced self-esteem (which can also result from insecure attachment), it can lead to maladaptive behaviour such as perfectionistic and compulsive behaviour to secure and stabilize self-worth and safety. Of the two dimensions that define insecure adulthood attachment (anxiety and avoidance), attachment anxiety is more closely related to OCD. While anxious attachment can lead to a worse response in acute treatment, secure attachment is a protective factor that can improve remission.
Conclusions: Anxious attachment is common in patients with OCD and interconnects with primary OCD symptomatology. From this perspective, strategies that promote feelings of safety, acceptance, and appreciation within a therapeutic relationship may be essential in treating OCD.
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Elife
January 2025
Institute of Parasitology, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Canada.
Paramyxovirus membrane fusion requires an attachment protein for receptor binding and a fusion protein for membrane fusion triggering. Nipah virus (NiV) attachment protein (G) binds to ephrinB2 or -B3 receptors, and fusion protein (F) mediates membrane fusion. NiV-F is a class I fusion protein and is activated by endosomal cleavage.
View Article and Find Full Text PDFJ Bacteriol
December 2024
School of Biological Sciences, University of Oklahoma, Norman, Oklahoma, USA.
Unlabelled: Ubiquitous in nature, biofilms provide stability in a fluctuating environment and provide protection from stressors. Biofilms formed in industrial processes are exceedingly problematic and costly. While biofilms of sulfate-reducing bacteria in the environment are often beneficial because of their capacity to remove toxic metals from water, in industrial pipelines, these biofilms cause a major economic impact due to their involvement in metal and concrete corrosion.
View Article and Find Full Text PDFClin Orthop Relat Res
December 2024
Department of Orthopedics, University of Colorado School of Medicine, Aurora, CO, USA.
Background: Patients with transfemoral amputation experience socket-related problems and musculoskeletal overuse injuries, both of which are exacerbated by asymmetric joint loading and alignment. Bone-anchored limbs are a promising alternative to treat chronic socket-related problems by directly attaching the prosthesis to the residual limb through an osseointegrated implant; however, it remains unknown how changes in alignment facilitated through a bone-anchored limb relate to loading asymmetry.
Questions/purposes: What is the association between femur-pelvis alignment and hip loading asymmetry during walking before and 12 months after transfemoral bone-anchored limb implantation?
Methods: Between 2019 and 2022, we performed 66 bone-anchored limb implantation surgeries on 63 individuals with chronic socket-related problems.
J Biomed Mater Res B Appl Biomater
January 2025
Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul, Republic of Korea.
Addressing the high cost and long cycle associated with the multistep digital restoration process involving 3D printing technology, we proposed the 3D pen as an innovative strategy for rapid bone repair. Capitalizing on the low melting point characteristic of polycaprolactone (PCL), we introduced, for the first time, the novel concept of directly constructing scaffolds at bone defect sites using 3D pens. In this in vitro study, we meticulously evaluated both the mechanical and biological properties of 3D pen-printed PCL scaffolds with six distinct textures: unidirectional (UNI) (0°, 45°, 90°), bidirectional (BID) (-45°/45°, 0°/90°), and concentric (CON).
View Article and Find Full Text PDFMicrosc Res Tech
January 2025
Department of Computer Science, Cihan University, Sulaimaniyah, Kurdistan Region, Iraq.
Waveguide evanescent field fluorescence microscopy (WEFF) is an evanescent-based microscopy that utilizes a confined thin film of light, around 100 nm, to image the plasma membrane of cells attached to a waveguide. Low photobleaching and low background besides its high axial resolution allows time-lapse imaging to investigate changes in cell morphology in the presence or absence of chemical agents. Both large field of view (FOV) and uniform illumination are very important while imaging cell-substrate contacts with an evanescent field.
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