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Pregnancy occurring in AA amyloidosis: a series of 27 patients including 3 new French cases.
J Nephrol
December 2024
Department of Internal Medicine, Centre de référence des maladies autoinflammatoires et des amyloses (CEREMAIA), DMU i3d, AP-HP, Hôpital Tenon, Service de Médecine Interne, Sorbonne University, Tenon Hospital, 75020, Paris, France.
Article Synopsis
- AA amyloidosis (AAA) is a serious multisystem disease stemming from chronic inflammation, commonly affecting the kidneys and posing risks during pregnancy.
- A study reviewed cases of AAA in pregnant women, identifying three new patients and highlighting that familial Mediterranean fever was the leading cause of AAA in this group.
- The research found that pregnancies in AAA patients often led to complications like growth retardation and preterm birth, indicating the need for heightened medical monitoring during pregnancy.
Long-term renal outcome of Cryopyrin-associated periodic syndrome (CAPS) under anti-Interleukin-1 therapy.
Sci Rep
July 2024
Department of Internal Medicine, Nephrology and Intensive Care Medicine, Phillips-University, Baldingerstraße 1, 35043, Marburg, Germany.
Cryopyrin-associated periodic syndromes (CAPS) are orphan hereditary auto-inflammatory diseases with various phenotypes, including chronic kidney disease (CKD). Current therapies inhibit interleukin-1 (IL-1) to achieve clinical and serological remission; however, the effect on kidney involvement remains unclear. The objective of this study was to investigate the long-term efficacy of anti-IL-1 treatment with special emphasis on renal outcome.
View Article and Find Full Text PDFAerobic physical training reduces severe asthma phenotype involving kinins pathway.
Mol Biol Rep
April 2024
Post-graduate Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Avenida Ana Costa 95, Santos, SP, 11060-001, Brazil.
Article Synopsis
- Aerobic physical training (APT) has been shown to decrease eosinophilic airway inflammation in asthma, but its specific effects and mechanisms in severe cases are still not fully understood.
- The study involved both in vitro experiments with human cells related to asthma and in vivo experiments with mice to observe the impact of APT on inflammatory markers and cell activity.
- Results indicated that APT reduced various inflammatory cytokines and other immune cell activities, improved lung function, and increased levels of the anti-inflammatory molecule IL-10, indicating a potential therapeutic role in managing severe asthma.
Successful desensitization to anakinra in a case with immediate cutaneous reaction in Still disease.
Rev Clin Esp (Barc)
April 2024
Unidad de Enfermedades Autoinmunes Sistémicas y Raras del adulto, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Stratum corneum and microbial biomarkers precede and characterize childhood atopic dermatitis.
J Eur Acad Dermatol Venereol
September 2024
Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.
Background: Atopic dermatitis (AD) is the most common paediatric inflammatory skin disease. There are currently no robust biomarkers that could reliably predict its manifestation, and on the molecular level, it is less well characterized than adult AD.
Objectives: This study aimed to extend previous findings and provide evidence for distinct changes of the epidermal proteome and microbiome preceding the onset of AD as well as characterizing early AD.
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