The relationship between hyperuricemia and polymorphisms of transporter genes in coronary artery disease (CAD) patients in China remains unclear. A total of 258 hyperuricemia patients with CAD and 242 control patients with CAD were recruited in this case-control study. Twenty-four SNPs in genes of , , , , , , and were genotyped using direct sequencing in all subjects. The mutation of rs2231142 locus increases the risk of hyperuricemia, and there is a gene dose effect in the influence of mutant heterozygotes and homozygotes. rs3825017 in and rs62293298 in were also confirmed to be associated with hyperuricemia. Age, weight, creatinine clearance rate, diuretics and SNPs on , and were all risk factors of hyperuricemia.
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