Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss in blood samples with low levels of circulating tumor DNA, and demonstrate its utility by profiling , , and genetic loss in metastatic prostate cancer patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422845 | PMC |
| http://dx.doi.org/10.3389/fonc.2021.720727 | DOI Listing |
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