AI Article Synopsis
- The number of COVID-19 cases in children is rising, but symptoms tend to be mild and the illness is usually short-lived.
- The virus enters cells via angiotensin-converting enzyme-2 (ACE2), and this interaction can lead to increased damage in organs like the lungs and heart.
- Research on ACE2 and the virus's spike protein is essential for advancing prevention strategies, treatment methods, and vaccine development for COVID-19.
Article Abstract
The cases of coronavirusdisease 2019 in children have been increasing with the ongoing pandemic.The finding suggests children have mild symptoms and a short course of the disease. Angiotensinconverting enzyme-2 mediates entry of the virus into the cell, the combination of virus and ACE2 leads to an increase in activity of angiotensin II, resulting in acute injury to lungs, myocardium and other organs. The infection causes down-regulation of ACE2 expression. The ACE2 plays an important role in the infection progression and clinical characteristics of COVID-19. Works on ACE2 and virus spike protein have future prospects of strategic information on prevention, management as well as vaccine development. Keywords: children;Coronavirus Disease 2019(COVID-19);SARS-Cov-2;angiotensin-Converting Enzyme 2 (ACE2).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654480 | PMC |
| http://dx.doi.org/10.31729/jnma.5436 | DOI Listing |
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