AI Article Synopsis
- A study was conducted to compare anti-TNFα drug levels in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) to see how treatment might be modified based on these levels.
- The research involved analyzing drug levels and the presence of anti-drug antibodies in patients receiving infliximab, adalimumab, and etanercept, using a specific testing method (ELISA).
- Findings revealed that while drug levels didn't vary significantly with disease activity, they did differ based on whether patients were also taking DMARDs.
Article Abstract
Background And Objectives: Knowledge of the levels of anti-TNFα drugs can modify treatment in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).
Objectives: To compare the levels of anti-TNFα in patients with RA vs SpA, in different clinical situations.
Materials And Methods: A retrospective, observational study was conducted. Levels of anti-TNFα and the presence of anti-drug antibodies were measured in consecutively selected patients, using the ELISA technique.
Results: Fifty-three, 73 and 78 patients treated with infliximab, adalimumab and etanercept were studied, respectively. The median drug levels in patients using standard doses were infliximab 2.2μg/ml (1.4-5.2), adalimumab 4.9μg/ml (0.8-8.9) and etanercept 3.1μg/ml (2.3-4.4). There were no differences in drug levels according to disease activity but we found differences in etanercept and infliximab levels according to DMARD use.
Conclusions: Levels of anti-TNFα drugs will change with DMARD treatment.
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| http://dx.doi.org/10.1016/j.reuma.2021.06.001 | DOI Listing |
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