AI Article Synopsis
- Research shows that abnormal microRNA (miRNA) expression is linked to tumor development, but the connection between miRNAs and non-functional pituitary adenomas (NFPA) is not well understood.
- * In this study, researchers compared the expression levels of four specific miRNAs (miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e) in blood samples from NFPA patients and healthy individuals to identify potential clinical biomarkers.
- * Results indicated that NFPA patients had significantly lower levels of these miRNAs compared to healthy controls, suggesting that they may play a role in NFPA's occurrence and progression, potentially serving as tumor suppressor genes.
Article Abstract
Background: The abnormal expression of microRNA (miRNA) has been proved to be closely related to the occurrence and progression of tumors. A unique expression of multiple miRNAs has been found in different types of tumors. However, the correlation between miRNA and non-functional pituitary adenoma (NFPA) is not clear. In this study, miRNAs (miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e) have been used as detection genes to compare the miRNA expression levels of NFPA subjects and healthy controls and to explore the expression of four different miRNAs in NFPA.
Methods: Ten untreated NFPA volunteers were served as subjects, and 10 normal subjects were selected as controls. Peripheral blood samples were collected, and four differentiated expressed miRNAs (miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e) obtained in the early stage of the test group were detected, recorded, and archived by quantitative real-time PCR (qPCR). The difference and significance of endogenous miRNA expressions were explored through statistical analysis, hoping to find biomarkers for clinical treatment.
Results: The levels of miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e in the peripheral serum of patients with NFPA were significantly lower than those in normal subjects (P < 0.05).
Conclusion: miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e may be involved in the occurrence and progress of NFPAs. This study aims to study the biological targets of NFPA. It starts from the study of whether miRNA, miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e may be tumor suppressor genes in NFPA, which provides a basis for further exploration of tumor markers of pituitary adenoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431909 | PMC |
| http://dx.doi.org/10.1186/s12957-021-02383-3 | DOI Listing |
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Potential biomarkers of miRNA in non-functional pituitary adenomas.
World J Surg Oncol
September 2021
Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No. 110 Ganhe Road, Hongkou District, Shanghai, 200437, China.
Article Synopsis
- Research shows that abnormal microRNA (miRNA) expression is linked to tumor development, but the connection between miRNAs and non-functional pituitary adenomas (NFPA) is not well understood.
- * In this study, researchers compared the expression levels of four specific miRNAs (miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e) in blood samples from NFPA patients and healthy individuals to identify potential clinical biomarkers.
- * Results indicated that NFPA patients had significantly lower levels of these miRNAs compared to healthy controls, suggesting that they may play a role in NFPA's occurrence and progression, potentially serving as tumor suppressor genes.
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