Targeting May Result in Enhanced Migration of Cancer Cells in Bladder Carcinoma.

Clinical bladder tumor histological analysis shows that high expression of is associated with poor patient prognosis. However, there are no studies that describe the underlying mechanism. To investigate the relative distribution and actual function of in bladder tumors, we analyzed multiple clinical databases in combination with tumor purity and immune cell infiltration simulations, as well as databases of well-defined histological phenotypes of bladder cancer, and single-cell sequencing of adjacent normal tissues and bladder tumors, and further compared them with bladder cancer cell lines. The results showed that expression was generally higher in normal tissues than in bladder cancer tissues, and its distribution was mainly in endothelial cells or immune cells. The association between high expression and poor prognosis may be due to tumor invasion of adjacent normal tissues, where highly expressed may affect prognostic interpretation. The effect of itself on cancer cells was associated with cell adhesion, and in bladder cancer cells, expression was negatively correlated with cell motility. Moreover, the use of FTY-720 will cause an increased metastatic ability of bladder cancer cells. In conclusion, we suggest that the use of -specific inhibition as a synergistic treatment requires more observation and consideration.