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Permanent cilia loss during cerebellar granule cell neurogenesis involves withdrawal of cilia maintenance and centriole capping.
Proc Natl Acad Sci U S A
December 2024
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Brain neurons utilize the primary cilium as a privileged compartment to detect and respond to extracellular ligands such as Sonic hedgehog (SHH). However, cilia in cerebellar granule cell (GC) neurons disassemble during differentiation through ultrastructurally unique intermediates, a process we refer to as cilia deconstruction. In addition, mature neurons do not reciliate despite having docked centrioles.
View Article and Find Full Text PDFDistinct roles of centriole distal appendage proteins in ciliary assembly and disassembly.
Cell Commun Signal
December 2024
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
The primary cilium is a cellular organelle whose assembly and disassembly are closely linked to the cell cycle. The centriole distal appendage (DA) is essential for the early stages of ciliogenesis by anchoring the mother centriole to the cell surface. Despite the identification of over twelve proteins constituting the DA, including CEP83, CEP89, CEP164, FBF1, and SCLT1, their specific functions in ciliary dynamics are not fully understood.
View Article and Find Full Text PDFNon-canonical CDK6 activity promotes cilia disassembly by suppressing axoneme polyglutamylation.
J Cell Biol
February 2025
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Tubulin polyglutamylation is a posttranslational modification that occurs primarily along the axoneme of cilia. Defective axoneme polyglutamylation impairs cilia function and has been correlated with ciliopathies, including Joubert Syndrome (JBTS). However, the precise mechanisms regulating proper axoneme polyglutamylation remain vague.
View Article and Find Full Text PDFThe open to closed D-loop conformational switch determines length in filopodia-like actin bundles.
Biochem J
December 2024
Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, U.K.
Article Synopsis
- Filopodia, microspikes, and cytonemes are structures in cells that help sense the environment and transport various materials across tissues, built mainly from bundles of actin filaments.
- The study discovered monoclonal antibodies that can elongate filopodia-like structures by targeting a specific part of actin filaments known as the D-loop.
- By preventing actin disassembly, these antibodies provide insights into how the length of filopodia is regulated, suggesting that keeping the actin filament D-loop in an open state promotes longer structures.
Visualizing Cartwheel Disassembly Process During Mitosis in Fixed and Live Cells by Fluorescence Microscope.
Methods Mol Biol
November 2024
The Academy for Cell and Life Health, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Centrosome is an evolutionarily conserved organelle that comprises two barrel-shaped centrioles surrounded by pericentriolar material (PCM). It functions as the major microtubule-organizing center (MTOC) to regulate cell polarity, motility, intracellular material transport during interphase, and bipolar spindle assembly during mitosis. Cartwheel assembly is considered the first step in the initiation of procentriole biogenesis at early S phase.
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