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Almost famous: Human adenoviruses (and what they have taught us about cancer). | LitMetric

Almost famous: Human adenoviruses (and what they have taught us about cancer).

Tumour Virus Res

Department of Microbiology and Immunology, The University of Western Ontario, London, ON, Canada; Department of Otolaryngology, Head & Neck Surgery, The University of Western Ontario, London, ON, Canada; Department of Oncology, The University of Western Ontario, London, ON, Canada; London Regional Cancer Program, Lawson Health Research Institute, London, ON, Canada. Electronic address:

Published: December 2021

AI Article Synopsis

Article Abstract

Papillomaviruses, polyomaviruses and adenoviruses are collectively categorized as the small DNA tumour viruses. Notably, human adenoviruses were the first human viruses demonstrated to be able to cause cancer, albeit in non-human animal models. Despite their long history, no human adenovirus is a known causative agent of human cancers, unlike a subset of their more famous cousins, including human papillomaviruses and human Merkel cell polyomavirus. Nevertheless, seminal research using human adenoviruses has been highly informative in understanding the basics of cell cycle control, gene expression, apoptosis and cell differentiation. This review highlights the contributions of human adenovirus research in advancing our knowledge of the molecular basis of cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449131PMC
http://dx.doi.org/10.1016/j.tvr.2021.200225DOI Listing

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