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HER2-Positive Serous Endometrial Cancer Treatment: Current Clinical Practice and Future Directions.
Medicina (Kaunas)
December 2024
5th Department of Oncology, Metropolitan General Hospital, 155 62 Athens, Greece.
The most common histological subtypes of endometrial cancer consist of endometrioid and uterine serous carcinoma, with the latter being more aggressive and accompanied by poor prognosis. Human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase receptor associated with cell proliferation, differentiation, and survival. HER2 positivity can be diagnosed in many solid tumors.
View Article and Find Full Text PDFCase report: High-grade serous tubo-ovarian carcinoma with fusion and insights into targetability.
Front Oncol
December 2024
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Article Synopsis
- Fusion is an emerging target in precision oncology, found in various solid tumors, but research is often focused on more common types, creating challenges in treatment planning for rare cases.
- The case presented involves a rare high-grade serous tubo-ovarian carcinoma with a unique fusion, which responded briefly to the drug futibatinib.
- The study explores the possible mechanisms behind this fusion and highlights difficulties in predicting how effective targeted therapies will be for different tumor types that share similar structural variants.
Tertiary lymphoid structures in high-grade serous tubo-ovarian carcinoma: anatomical site matters.
Cancer Immunol Immunother
January 2025
Division of Oncology, Department of Clinical Sciences Lund, and Lund University Cancer Center, Lund University, Lund, Sweden.
Tertiary lymphoid structures (TLS) in the tumor microenvironment are prognostically beneficial in many solid cancer types. Reports on TLS in high-grade serous tubo-ovarian carcinoma (HGSC) are few, and the prognostic impact is unclear. We investigated mature TLS (mTLS), immature TLS (iTLS) and lymphoid aggregates (LA) in primary adnexal tumors (PTs) and synchronous omental/peritoneal metastases (pMets) of HGSC.
View Article and Find Full Text PDFPreoperative magnetic resonance evaluation of Struma Ovarii and its importance for the surgical modality: a retrospective study from two institutions.
Abdom Radiol (NY)
January 2025
Department of Radiology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Objectives: To improve preoperative diagnostic accuracy of struma ovarii by retrospectively reviewing magnetic resonance (MR) findings. It is beneficial to choose the most appropriate surgical modality for the patient.
Methods: We retrospectively reviewed the clinical course and MR characteristics of 52 patients who were diagnosed postoperatively with struma ovarii, pathologically, from two institutions.
Prognostic implication of CD47 and CTLA-4 expressions in endometrial carcinoma.
Hum Immunol
December 2024
Pathology Department, Faculty of Medicine, Zagazig University, Egypt.
Background: CD47 is an immune-regulatory protein that belongs to the immunoglobulin family. It inhibits the phagocytic ability of immune cells. So, it is related to an unfavorable outcome in leukemia and various solid tumors.
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