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Effects of antihypertensives with and without IL-6 lowering properties on long-term blood pressure control: The prospective HELIUS cohort.
Int J Cardiol Cardiovasc Risk Prev
March 2025
Department of Public and Occupational Health, Amsterdam Public health Research Institute, Amsterdam university Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Article Synopsis
- Chronic inflammation, particularly the role of interleukin-6 (IL-6), is being explored as a target for improving hypertension treatment.
- In a study involving 1,510 participants over six years, it was found that calcium channel blockers (CCBs) with IL-6-lowering properties (specifically amlodipine and barnidipine) resulted in better blood pressure control compared to other CCBs.
- No significant differences were seen in blood pressure control among other antihypertensive classes or across different ethnic groups, indicating a need for further research into IL-6's impact on hypertension management.
Evaluation of diflubenzuron-verapamil combination strategy for eco-safe management of .
Front Physiol
December 2024
Department of Zoology, Acharya Narendra Dev College, University of Delhi, New Delhi, India.
Introduction: , the vector of multiple arboviral diseases, is a prime health concern worldwide. The surge in borne diseases emphasizes the urgent need for efficient vector control measures. Synthetic pesticides used traditionally, however, present environmental concerns and issues like resistance development, causing the use of higher chemical doses.
View Article and Find Full Text PDFIdentification and characterization of ATP-binding cassette transporters involved in chlorantraniliprole tolerance of model insect Drosophila melanogaster and agricultural pest Spodoptera frugiperda.
Pestic Biochem Physiol
December 2024
Department of Entomology and BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA.
ATP-binding cassette (ABC) transporter family is one of the largest transporter families, which plays an important role in insecticide tolerance. In this study, we found that the ABC transporter inhibitor verapamil could significantly enhance the toxicity of chlorantraniliprole (CHL) to the model insect Drosophila melanogaster. Forty-six ABC transporter genes of D.
View Article and Find Full Text PDFAge-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks.
Poult Sci
November 2024
State Key Laboratory of Swine and Poultry Breeding Industry/Institute of Animal Science, Guangdong Academy of Agricultural Sciences/Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs/ Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, PR China. Electronic address:
The ovary is the main controller of female fertility, unfortunately, its onset of aging processes was earlier than other organs. Our previous studies showed calcium (Ca) deficiency reduced ovarian weight and declined numbers of dominant follicles in an avian model. However, whether Ca provided a functional role in follicle development of aged avian, and its further mechanism was still unknown.
View Article and Find Full Text PDFCharacterization of a Hypothetical Protein (PBJ89160.1) from Exhibits a New Insight on Nutritional Virulence and Molecular Docking to Uncover a Therapeutic Target.
Evol Bioinform Online
November 2024
Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh.
Article Synopsis
- The study aims to enhance understanding of the bacterial meningitis-causing diplococcus by identifying a functional protein that could be targeted for future treatments.
- Using a hypothetical protein (HP), researchers employed various bioinformatics methods and homology modeling to predict the protein's structure and function.
- Results indicated that HP is acidic and soluble, is localized in the periplasm, and Loperamide shows the best potential as a therapeutic agent by inhibiting the protein's transporter activity.
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