Two new polyisoprenylated benzophenones, planchoniones A () and B (), together with two known benzophenones () and six known xanthones (), were isolated from an ethyl acetate extract of the pericarp of Pierre. Their structures were established using spectroscopic methods, mainly 1D and 2D NMR. The four benzophenones were evaluated for their cytotoxicity against MCF-7 human breast cancer cells, and showed almost no activity. Meanwhile, compounds - were investigated for their inhibitory effects towards α-glucosidase, and γ-mangostin (5) exhibited the most remarkable effect with IC value of 15.3 ± 0.9 µM (compared with acarbose, IC = 224.9 ± 3.6 µM).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2021.1960328 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Garcinol in gastrointestinal cancer prevention: recent advances and future prospects.
J Cancer Res Clin Oncol
July 2024
Laboratory of Animal Immunology and Biotechnology, Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, 61300, Brno, Czech Republic.
Gastrointestinal cancers continue to pose a significant global health challenge, with millions of new cases diagnosed each year. Despite advancements in treatment, the prognosis for many patients remains poor. This article explores the potential of garcinol, a polyisoprenylated benzophenone found in various Garcinia species, as a therapeutic agent against gastrointestinal malignancies.
View Article and Find Full Text PDFGarcinol prevents oxidative stress-induced bone loss and dysfunction of BMSCs through NRF2-antioxidant signaling.
Cell Death Discov
February 2024
Department of Orthopaedics, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
There are multiple published data showing that excessive oxidative stress contributes to bone loss and even bone tissue damage, and it is also correlated with the pathophysiology of bone degenerative diseases, including osteoporosis (OP). Garcinol, a polyisoprenylated benzophenone derivative, has been recently established as an anti-oxidant agent. However, it remains elusive whether Garcinol protects bone marrow mesenchymal stem cells (BMSCs) and bone tissue from oxidative stress-induced damage.
View Article and Find Full Text PDFChemometric assisted natural DES based VA-DLLME-LC-MS/MS method for the quantitative determination of Garcinol in biofluids/tissues: A practical application to pharmacokinetics and biodistribution studies.
J Pharm Biomed Anal
October 2023
Analytical and Structural Chemistry Department, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Analytical Division, Institute of Pesticide Formulation Technology (IPFT), Sector-20, Udyog Vihar, Gurugram-122016, Haryana. Electronic address:
Garcinol (GAR) is a polyisoprenylated benzophenone obtained from Garcinia indica used as anti-oxidant and anti-inflammatory in traditional medicine and due to these activities, it possesses anticancer properties. It is considered to be a next generation epigenetic drug. A green solvent based analytical method which is efficient, sophisticated, and highly enriched has been developed for the quantitative analysis of GAR in biological samples (plasma, liver, kidney and spleen) with the use of deep eutectic solvent (DES) for its extraction.
View Article and Find Full Text PDFGarcinol-Attenuated Gastric Ulcer (GU) Experimentally Induced in Rats Via Affecting Inflammation, Cell Proliferation, and DNA Polymerization.
Cureus
August 2023
Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, SAU.
Background: Gastric ulcer (GU) is one of the most critical gastrointestinal tract disorders. Garcinol is a polyisoprenylated benzophenone in Garcinia fruit with antioxidant and anti-inflammatory priorities.
Objectives: We aimed to assess the protective effects of garcinol against GU induced in rats.
Garcinol acts as a novel integrin αβ inhibitor in human platelets.
Life Sci
August 2023
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. Electronic address:
Aims: Platelet activation plays a central role in arterial thrombosis. Platelets are activated by adhesive proteins (i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!