A new ingol diterpenoid, namely 3-de--acetyleuphornan R (), along with two known analogues, euphornans E () and N () were isolated from the seeds of Pursh. The structure of was elucidated by extensive H NMR, C NMR, HSQC, HMBC, and H-H COSY, and HR-MS spectroscopic analyses.
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http://dx.doi.org/10.1080/14786419.2021.1948846 | DOI Listing |
Nat Prod Res
June 2024
Department of Natural Products, Institute of Drug Technology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Two unusual phorbol esters, namely 20-deoxyphorbol-3,4,12-triacetate-13-phenylacetate () and phorbol-3,4,12,13-tetraacetate-20-phenylacetate () plus ingol-3,8,12-triacetate-7-phenylacetate () were isolated from the latex of and identified by HRESIMS and 2D NMR. Compound is herein described for the first time. Assignment of the phenylacetyl group at C-7 in compound was suggested by the HMBC and NOESY spectra obtained in pyridine-.
View Article and Find Full Text PDFPhytochemistry
September 2023
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China; Research Units of Discovery of New Drug Lead Molecules, Chinese Academy of Medical Sciences, Shanghai, 201203, China. Electronic address:
Nine undescribed diterpenoids, euphlactenoids A-I (1-9), including four ingol-type diterpenoids (1-4) with a 5/3/11/3-tetracyclic framework and five ent-pimarane-type diterpenoids (5-9), together with thirteen known diterpenoids (10-22), were identified from the leaves and stems of Euphorbia lactea Haw. The structures and absolute configurations of compounds 1-9 were unequivocally elucidated on the basis of spectroscopic analysis, ECD calculations and single crystal X-ray diffraction. Compounds 3 and 16 showed anti-HIV-1 effects with IC values of 1.
View Article and Find Full Text PDFMetabolites
April 2023
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
plants have a significant place in traditional medicine due to their numerous therapeutic properties, including their anti-tumor effects, which have been observed in several species. In the current study, a phytochemical investigation of methanolic extract led to the isolation and characterization of four secondary metabolites from the chloroform (CHCl) and ethyl acetate (EtOAc) fractions, which are reported for the first time in this species. One of the constituents, saudiarabicain F (), is a rare C-19 oxidized ingol-type diterpenoid that has not been previously reported.
View Article and Find Full Text PDFMolecules
October 2022
Faculdade de Ciências e Tecnologia, Campus de Gambelas, Universidade do Algarve, 8005-139 Faro, Portugal.
L. is a Moroccan endemic plant known as "Tikiout" and "Daghmus" that can also be found in Mauritania, Western Sahara, and Algeria. In the present review, "", "metabolites" "hemisynthesis" were the keywords used for the research in the Web search engine Google Scholar and in the database Web of Science.
View Article and Find Full Text PDFMolecules
August 2022
Laboratoire de Chimie Physique et Biotechnologie des Biomolécules et des Matériaux, Faculté des Sciences et Techniques, Université Hassan II Casablanca, BP 146, Mohammedia 28800, Morocco.
latex has been extensively utilized in traditional medicine due to its range of bioactivities. Chromatographic separations on silica gel of ethanol extract of latex led to the development of a new procedure for isolating resiniferatoxin () via dried latex and the identification of nine compounds. Among these, catechol (), protocatechuic acid () and 3,4-dihydroxyphenylacetic acid (), known phenolic compounds, were identified for the first time in latex.
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