Background: The aim of this study was to assess the current perinatal telemedicine (PTM) landscape and inform the design and implementation of a PTM network linking level I/II birthing hospitals with the two-level IV hospitals in Maryland, to improve access to maternal-fetal medicine (MFM) specialist care.
Methods: Qualitative in-depth interviews were conducted with 24 clinicians and telemedicine experts during July-September 2020. We obtained data on 12 level I/II and both level IV hospitals.
Results: Less than half of level I/II hospitals currently offer obstetric services through telemedicine, and both level IV hospitals have interest and technical capacity to support implementation of a PTM network in Maryland. The COVID-19 related shift to telehealth and telemedicine was identified as a facilitator for such PTM programs. Perceived barriers to provider adoption of PTM services and network in Maryland included hospital leadership buy-in, information technology (IT) literacy, and patient triage complexities. Perceived barriers to patient adoption of PTM were access to technology, IT literacy, and language. Key benefits of PTM services included overall improved patient access, convenience, cost-savings, and safety during the COVID-19 pandemic. Influential factors for implementing a PTM network in Maryland included buy-in and approval from hospital and health system administration, a streamlined telehealth platform allowing for electronic medical record integration and interoperability, program funding, and sustainability.
Conclusions: Gaps in availability of MFM care at level I/II birth hospitals call for expanded telemedicine programming to improve high-risk patients' access to specialty obstetric care and support the development of a PTM network in Maryland.
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http://dx.doi.org/10.23736/S2724-606X.21.04933-2 | DOI Listing |
Front Genet
January 2025
School of Information and Artificial Intelligence, Anhui Agricultural University, Hefei, Anhui, China.
Cysteine S-carboxyethylation, a novel post-translational modification (PTM), plays a critical role in the pathogenesis of autoimmune diseases, particularly ankylosing spondylitis. Accurate identification of S-carboxyethylation modification sites is essential for elucidating their functional mechanisms. Unfortunately, there are currently no computational tools that can accurately predict these sites, posing a significant challenge to this area of research.
View Article and Find Full Text PDFClin Transplant
January 2025
Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Introduction: Patients with congenital heart disease (CHD) are at increased risk of cancer. In patients with CHD and advanced heart failure, isolated heart transplantation (HT) can be considered. In the overall HT population, immunosuppression after HT increases the risk of post-transplant malignancy (PTM).
View Article and Find Full Text PDFSci Adv
January 2025
Department of Biostatistics and Health Data Science, School of Medicine, Indiana University, Indianapolis, IN 46202, USA.
Alzheimer's disease (AD) is the leading dementia among the elderly with complex origins. Despite extensive investigation into the AD-associated protein-coding genes, the involvement of noncoding RNAs (ncRNAs) and posttranscriptional modification (PTM) in AD pathogenesis remains unclear. Here, we comprehensively characterized the landscape of ncRNAs and PTM events in 1460 samples across six brain regions sourced from the Mount Sinai/JJ Peters VA Medical Center Brain Bank Study and Mayo cohorts, encompassing 33,321 long ncRNAs, 92,897 enhancer RNAs, 53,763 alternative polyadenylation events, and 900,221 A-to-I RNA editing events.
View Article and Find Full Text PDFJ Exp Bot
December 2024
Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
In aerobic life forms, reactive oxygen species (ROS) are produced by the partial reduction of oxygen during energy-generating metabolic processes. In plants, ROS production increases during periods of both abiotic and biotic stress, severely overloading the antioxidant systems. Hydrogen peroxide (H2O2) plays a central role in cellular redox homeostasis and signaling by oxidising crucial cysteines to sulfenic acid, which is considered a biologically relevant post-translational modification (PTM).
View Article and Find Full Text PDFbioRxiv
December 2024
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22903.
Evolution has developed a set of principles that determine feasible domain combinations analogous to grammar within natural languages. Treating domains as words and proteins as sentences, made up of words, we apply a linguistic approach to represent the human proteome as an n-gram network. Combining this with network theory and application, we explore the functional language and rules of the human proteome.
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