Haemoglobin (Hb)-albumin (HSA) trimers were synthesized using five distinct Hb variants in which the structures were genetically and chemically tuned as an artificial O carrier and used as a red blood cell (RBC) substitute. The trimers were found to have moderately low O affinity ( = 23-34 Torr, 37 °C) and high co-operativity, yielding a maximum O transport efficiency 1.8-fold higher than that of human RBCs.
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| http://dx.doi.org/10.1039/d1cc03684j | DOI Listing |
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