AI Article Synopsis
- The right and left ventricles of the heart have typically been studied separately, with little understanding of how diseases in one affect the other.
- This review highlights the distinct differences between the two ventricles in both healthy and diseased states and emphasizes the need for better knowledge of right ventricle dysfunction.
- The article also examines current therapies and research aimed at treating right ventricle failure, particularly in the context of pulmonary arterial hypertension, which is a significant factor in patient mortality.
Article Abstract
The right and left ventricles have traditionally been studied as individual entities. Furthermore, modifications found in diseased left ventricles are assumed to influence on right ventricle alterations, but the connection is poorly understood. In this review, we describe the differences between ventricles under physiological and pathological conditions. Understanding the mechanisms that differentiate both ventricles would facilitate a more effective use of therapeutics and broaden our knowledge of right ventricle (RV) dysfunction. RV failure is the strongest predictor of mortality in pulmonary arterial hypertension, but at present, there are no definitive therapies directly targeting RV failure. We further explore the current state of drugs and molecules that improve RV failure in experimental therapeutics and clinical trials to treat pulmonary arterial hypertension and provide evidence of their potential benefits in heart failure.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421158 | PMC |
| http://dx.doi.org/10.1155/2021/9993060 | DOI Listing |
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