Skin cancer is one of the most common types of cancers that is sometimes difficult for doctors and experts to diagnose. The noninvasive dermatoscopic method is a popular method for observing and diagnosing skin cancer. Because this method is based on ocular inference, the skin cancer diagnosis by the dermatologists is difficult, especially in the early stages of the disease. Artificial intelligence is a proper complementary tool that can be used alongside the experts to increase the accuracy of the diagnosis. In the present study, a new computer-aided method has been introduced for the diagnosis of the skin cancer. The method is designed based on combination of deep learning and a newly introduced metaheuristic algorithm, namely, Wildebeest Herd Optimization (WHO) Algorithm. The method uses an Inception convolutional neural network for the initial features' extraction. Afterward, the WHO algorithm has been employed for selecting the useful features to decrease the analysis time complexity. The method is then performed to an ISIC-2008 skin cancer dataset. Final results of the feature selection based on the proposed WHO are compared with three other algorithms, and the results have indicated good results for the system. Finally, the total diagnosis system has been compared with five other methods to indicate its effectiveness against the studied methods. Final results showed that the proposed method has the best results than the comparative methods.
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http://dx.doi.org/10.1155/2021/7567870 | DOI Listing |
Viruses
January 2025
MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK.
Different types of feline papillomaviruses (PVs) are associated with a variety of skin lesions and neoplasia, such as papillomas and cell carcinomas, but the virus can also be found in healthy skin. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of veterinary experts on feline infectious diseases from 11 European Countries, discusses the current knowledge of feline PV infections. Cats most likely become infected through lesions or abrasions of the skin.
View Article and Find Full Text PDFPharmaceutics
December 2024
Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, Brasília 70910-900, Brazil.
: This study aimed to evaluate the safety and efficacy of chitosan-based bioadhesive films for facilitating the topical delivery of curcumin in skin cancer treatment, addressing the pharmacokinetic limitations associated with oral administration. : The films, which incorporated curcumin, were formulated using varying proportions of chitosan, polyvinyl alcohol, Poloxamer 407, and propylene glycol. These films were assessed for stability, drug release, in vitro skin permeation, cell viability (with and without radiotherapy), and skin irritation.
View Article and Find Full Text PDFPharmaceutics
December 2024
School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand.
Skin ageing, driven predominantly by oxidative stress from reactive oxygen species (ROS) induced by environmental factors like ultraviolet A (UVA) radiation, accounts for approximately 80% of extrinsic skin damage. L-glutathione (GSH), a potent antioxidant, holds promise in combating UVA-induced oxidative stress. However, its instability and limited penetration through the stratum corneum hinder its topical application.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
School of Science and Engineering, University of Dundee, Dundee DD1 4HN, UK.
Nanofibrous dressing materials with an antitumor function can potentially inhibit recurrence of melanoma following the surgical excision of skin tumors. In this study, hydrolyzed polyacrylonitrile (hPAN) nanofibers biofunctionalized with L-carnosine (CAR) and loaded with bio (CAR)-synthesized zinc oxide (ZnO) nanoparticles, ZnO/CAR-hPAN (hereafter called ZCPAN), were employed to develop an antimelanoma wound dressing. Inspired by the formulation of the commercial wound healing Zn-CAR complex, i.
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
Instituto de Química, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 37130-000, MG, Brazil.
Background: Melanoma is the most aggressive and lethal skin cancer that affects thousands of people worldwide. Ruthenium complexes have shown promising results as cancer chemotherapeutics, offering several advantages over platinum drugs, such as potent efficacy, low toxicity, and less drug resistance. Additionally, anthraquinone derivatives have broad therapeutic applications, including melanoma.
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