AI Article Synopsis

  • The study aimed to develop a thermosensitive hydrogel for local delivery of the antibiotic metronidazole (MTZ) to combat periodontal infections while minimizing antibiotic resistance and side effects associated with systemic treatments.
  • The hydrogel was created using Pluronic F127, methylcellulose, and silk fibroin, and its properties were analyzed, revealing effective sol-gel transitions and prolonged MTZ release over 10 days.
  • The results suggest that MTZ-thermosensitive hydrogels are a promising local drug delivery option for enhancing treatment outcomes in periodontitis.

Article Abstract

Objectives: Periodontal treatment focuses on the thorough removal of specific periodontal pathogens, mainly anaerobic Gram-negative bacteria, by mechanical scaling and root planning. In case the periodontal abscess is detected after treatment, a high dose of antimicrobial agents is commonly applied via oral administration. However, this approach increases the risk of antibiotic resistance and systemic side effects and decreases efficacy. To overcome the aforementioned issues, this study focused on the development of thermosensitive hydrogel to deliver the antibiotic drug metronidazole (MTZ) directly and locally to the oral infection site.

Materials And Methods: The thermosensitive hydrogels were prepared by blending 28% w/v Pluronic F127 with various concentrations of methylcellulose (MC) and silk fibroin (SF). The gel properties, such as sol-gel transition time, viscosity, and gel strength, were investigated. The drug dissolution profiles, together with their theoretical models and gel dissolution characteristics, were also determined.

Results: All hydrogel formulations exhibited sol-gel transitions at 37°C within 1 min. An increase in MC content proportionally increased the viscosity but decreased the gel strength of the hydrogel. By contrast, the SF content did not significantly affect the viscosity but increased the gel strength of the hydrogel. The thermosensitive hydrogels also showed prolonged MTZ release characteristics for 10 days in phosphate-buffered saline (PBS) at pH 6.6, which followed the Higuchi diffusion model. Moreover, MTZ-thermosensitive hydrogel exhibited delayed dissolution in PBS at 37°C for more than 9 days.

Conclusion: MTZ-thermosensitive hydrogels could be considered a prospective local oral drug delivery system to achieve efficient sustained release and improve the drug pharmacological properties in periodontitis treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430413PMC
http://dx.doi.org/10.4274/tjps.galenos.2020.09623DOI Listing

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