Universal scanning-free initiation of eukaryote protein translation-a new normal.

Biomol Concepts

Department of Biochemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.

Published: September 2021

A unique feature of eukaryote initiation of protein translation is a so-called scanning of 5'-untranslated region (5'-UTR) by a ribosome initiation complex to enable bound Met-tRNA access to the initiation codon located further downstream. Here, we propose a universal scanning-free translation initiation model that is independent of 5'-UTR length and applicable to both 5'-mG (capped) and uncapped mRNAs.

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Source
http://dx.doi.org/10.1515/bmc-2021-0014DOI Listing

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