A unique feature of eukaryote initiation of protein translation is a so-called scanning of 5'-untranslated region (5'-UTR) by a ribosome initiation complex to enable bound Met-tRNA access to the initiation codon located further downstream. Here, we propose a universal scanning-free translation initiation model that is independent of 5'-UTR length and applicable to both 5'-mG (capped) and uncapped mRNAs.
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http://dx.doi.org/10.1515/bmc-2021-0014 | DOI Listing |
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